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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2024; 30(21): 2734-2739
Published online Jun 7, 2024. doi: 10.3748/wjg.v30.i21.2734
Published online Jun 7, 2024. doi: 10.3748/wjg.v30.i21.2734
Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer
Shi-Yan Yan, Jian-Gao Fan, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Author contributions: Yan SY designed the overall concept and outline of the manuscript; Fan JG contributed to the discussion and design of the manuscript; Yan SY and Fan JG contributed to the writing and editing of the manuscript, illustrations, and literature review.
Conflict-of-interest statement: Both authors disclose that there is no conflict of interest related to this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Gao Fan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. fattyliver2004@126.com
Received: February 6, 2024
Revised: April 18, 2024
Accepted: May 16, 2024
Published online: June 7, 2024
Processing time: 118 Days and 4.3 Hours
Revised: April 18, 2024
Accepted: May 16, 2024
Published online: June 7, 2024
Processing time: 118 Days and 4.3 Hours
Core Tip
Core Tip: The immune checkpoint proteins including PD-1/PD-L1, cytotoxic T-lymphocyte antigen-4 play significant roles in the field of cancer immunotherapy. As a result, monoclonal antibodies block these immune checkpoint proteins have been utilized broadly in patients with gastric cancer (GC). However, the treatment-emergent adverse events of autoimmune-like toxicities in patients treated with immune-related immune checkpoint inhibitors (ICIs) have also been observed. These may be related to microsatellite instability (MSI). So, it is important to detect MSI before applying ICIs for treatment of GC.