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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2024; 30(20): 2624-2628
Published online May 28, 2024. doi: 10.3748/wjg.v30.i20.2624
Published online May 28, 2024. doi: 10.3748/wjg.v30.i20.2624
Metadherin-driven promotion of cancer stem cell phenotypes and its effect on immunity in hepatocellular carcinoma
Nevena Todorović, Amedeo Amedei, Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy
Nevena Todorović, Clinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, Belgrade 11000, Serbia
Author contributions: Todorović N and Amedei A designed the overall concept and outline of the manuscript, contributed to the writing and editing the manuscript; Todorović N reviewed the literature; Amedei A supervised and revised the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amedeo Amedei, MSc, Full Professor, Department of Experimental and Clinical Medicine, University of Florence, 3 Largo Brambilla, Florence 50134, Italy. amedeo.amedei@unifi.it
Received: February 29, 2024
Revised: April 24, 2024
Accepted: May 9, 2024
Published online: May 28, 2024
Processing time: 88 Days and 6 Hours
Revised: April 24, 2024
Accepted: May 9, 2024
Published online: May 28, 2024
Processing time: 88 Days and 6 Hours
Core Tip
Core Tip: Metadherin (MTDH) is a protein and a predictor of poor prognosis, of aggressive tumor phenotypes prone to metastasis, recurrence, and therapy resistance in hepatocellular carcinoma (HCC). Several studies have demonstrated a correlation between MTDH and cancer stem cells, which has elevated interest in further investigating this oncogene and its impacts to a higher level. The editorial highlights the ongoing research in the HCC field, revealing the significance for future studies.