Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2024; 30(19): 2575-2602
Published online May 21, 2024. doi: 10.3748/wjg.v30.i19.2575
Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma
Tian Peng, Fang Sun, Jia-Chun Yang, Mei-Hong Cai, Man-Xiu Huai, Jia-Xing Pan, Fei-Yu Zhang, Lei-Ming Xu
Tian Peng, Fang Sun, Jia-Chun Yang, Mei-Hong Cai, Man-Xiu Huai, Jia-Xing Pan, Fei-Yu Zhang, Lei-Ming Xu, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200092, China
Co-first authors: Tian Peng and Fang Sun.
Author contributions: Peng T and Sun F contributed equally; Peng T, Sun F and Xu L designed the research; Peng T and Sun F performed the research; Yang J and Cai M contributed new reagents, Huai M and Pan J contributed analytic tools; Peng T, Sun F and Zhang F analyzed the data; Peng T, Sun F and Xu L wrote the paper.
Supported by National Natural Science Foundation of China, No. 82172737; and Shanghai Science and Technology Development Funds (Shanghai Sailing Program), No. 22YF1427600.
Institutional animal care and use committee statement: The study was reviewed and approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Approval No. XHEC-F-2023-075).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Statistical code, and dataset available from the corresponding author at xuleiming@xinhuamed.com.cn. Participants gave informed consent for data sharing.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei-Ming Xu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Shanghai 200092, China. xuleiming@xinhuamed.com.cn
Received: February 3, 2024
Revised: March 9, 2024
Accepted: April 24, 2024
Published online: May 21, 2024
Processing time: 106 Days and 17.4 Hours
Core Tip

Core Tip: Our article presents the first study on lactylation modification in pancreatic cancer, establishing a lactylation-related signature that offers new strategic directions for tumor prognosis prediction and combination antitumor immunotherapy. It employs an innovative approach, combining both dry lab and wet lab experimental methods, to validate the genes most closely associated with lactylation.