Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2024; 30(18): 2467-2478
Published online May 14, 2024. doi: 10.3748/wjg.v30.i18.2467
Overlapping approach Proton Pump Inhibitors/Nux vomica-Heel as new intervention for gastro-esophageal reflux management: Delphi consensus study
Edda Battaglia, Luciano Bertolusso, Marco Del Prete, Marco Monzani, Marco Astegiano
Edda Battaglia, Gastroenterology Unit, ASLTO4, Ivrea 10015, Turin, Italy
Luciano Bertolusso, General Practitioner, ASL CN2, Alba - Bra 12051, Cuneo, Italy
Marco Del Prete, Specialist in Nephrology International Academy of Physiological Regulating Medicine, Milan 20100, Italy
Marco Monzani, Specialist in Endocrinology, Territorial Social and Health Authority of Brianza, Monza 20900, Italy
Marco Astegiano, Gastroenterology Specialist, Retired from Gastroenterology and Hepatology Unit, AOU Città della Salute e della Scienza, Turin 10123, Italy
Author contributions: Battaglia E, Bertolusso L, Del Prete M, Monzani M and Astegiano M contributed to the conception and the process of Consensus and to the writing of the article; All Authors have read and approve the final manuscript.
Supported by Guna S.p.a. (unconditional granted).
Conflict-of-interest statement: Dr. Battaglia reports grants from NZP-UK, personal fees from Europharma, grants from Guna S.p.a., outside the submitted work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Edda Battaglia, MD, Director, Gastroenterology Unit, ASLTO4, Piazza Credenza 2, Ivrea 10015, Turin, Italy. edda.battaglia@gmail.com
Received: January 21, 2024
Revised: February 28, 2024
Accepted: April 16, 2024
Published online: May 14, 2024
Processing time: 110 Days and 16.8 Hours
Core Tip

Core Tip: This Delphi consensus suggests Nux vomica-Heel as a new therapeutic tool for the medical doctor who daily finds himself diagnosing and treating gastro-esophageal reflux disease (GERD). Nux vomica-Heel is a multicomponent/multitarget low dose medication that can be introduced in the patient’s therapeutic plan in overlapping with Proton Pump Inhibitors (PPIs) to progressively reduce the use of PPIs through an appropriate decalage plan. All the statements were approved with a large majority by a panel of gastroenterologists, otolaryngologists, geriatrics, and general practitioners expert in GERD, demonstrating their validity and the importance of the topic covered by the consensus.