Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2024; 30(18): 2454-2466
Published online May 14, 2024. doi: 10.3748/wjg.v30.i18.2454
Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury
Si-Miao Yu, Hao-Cheng Zheng, Si-Ci Wang, Wen-Ya Rong, Ping Li, Jing Jing, Ting-Ting He, Jia-Hui Li, Xia Ding, Rui-Lin Wang
Si-Miao Yu, Hao-Cheng Zheng, Si-Ci Wang, Ping Li, Xia Ding, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Wen-Ya Rong, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Jing Jing, Ting-Ting He, Rui-Lin Wang, Department of Hepatology of Traditional Chinese Medicine, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China
Jia-Hui Li, The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, Henan Province, China
Co-first authors: Si-Miao Yu and Si-Ci Wang.
Co-corresponding authors: Xia Ding and Rui-Lin Wang.
Author contributions: Yu SM designed and wrote the manuscript; Wang SC, Zheng HC, and Rong WY analyzed the data; Jing J, He TT, Li P, and Li JH screened the literature and collected the data; Ding X and Wang RL critically revised the manuscript. All authors finally read and approved the version to be published. Yu SM and Wang SC contributed equally to this work as co-first authors. The reasons are the following. First, the research was performed as a collaborative effort, and the designation of co-first authors authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. Second, co-first authors contributed efforts of equal substance throughout the research process. Ding X and Wang RL contributed equally to this work as co-corresponding authors. The reasons are the following. First, they played a key role in coordinating the research team. Second, they made a great contribution to the original innovation of the article. In summary, we believe that designating Yu SM and Wang SC as co-first authors, Ding X and Wang RL as co-corresponding authors is fitting for our manuscript as it accurately reflects our team’s collaborative spirit, equal contributions, and diversity.
Supported by Medical Education Association Foundation of China, No. 2020KTY001; National Natural Science Foundation of China, No. 81673806; and National Natural Science Foundation Youth Fund, No. 82104702.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Fifth Medical Center of PLA General Hospital (2020050D).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui-Lin Wang, M.D, Department of Hepatology of Traditional Chinese Medicine, The Fifth Medical Center of PLA General Hospital, No. 100 Middle Road, West Fourth Ring Road, Beijing 100039, China. WRL7905@163.com.
Received: February 20, 2024
Revised: April 5, 2024
Accepted: April 18, 2024
Published online: May 14, 2024
Processing time: 81 Days and 4.5 Hours
Core Tip

Core Tip: Drug-induced liver injury (DILI) is one of the most common and serious adverse reactions to drugs. Conventional biomarkers are not specific and there is an urgent need for a non-invasive DILI marker. Our study has revealed a significant difference in salivary metabolites between patients with DILI and healthy individuals, and identified five metabolites that can distinguish DILI from healthy control, namely 12-hydroxydodecanoic acid, 3-hydroxydecanoic acid, tetradecanedioic acid, hypoxanthine, and inosine. Our study may provide a potential feasible non-invasive diagnostic method for DILI.