Hepatic perivascular epithelioid cell tumors: Benign, malignant, and uncertain malignant potential

doi:10.3748/wjg.v30.i18.2374

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May 14, 2024 (publication date) through Jul 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2024; 30(18): 2374-2378
Published online May 14, 2024. doi: 10.3748/wjg.v30.i18.2374

Hepatic perivascular epithelioid cell tumors: Benign, malignant, and uncertain malignant potential

Marcelo Fabián Amante

Marcelo Fabián Amante, División Patología, Hospital General de Agudos Cosme Argerich, Buenos Aires C1155AHA, Argentina

Marcelo Fabián Amante, División Patología, Hospital Alemán de Buenos Aires, Buenos Aires C1155AHA, Argentina

Author contributions: Amante MF designed the report, reviewed the existing literature, analyzed the data, and wrote the paper.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Corresponding author: Marcelo Fabián Amante, MD, Chief Doctor, División Patología, Hospital General de Agudos Cosme Argerich, Pi y Margall 480, 13H, Buenos Aires C1155AHA, Argentina. marcelofabianamante@gmail.com

Received: December 24, 2023
Revised: February 20, 2024
Accepted: April 25, 2024
Published online: May 14, 2024
Processing time: 139 Days and 10.2 Hours

Core Tip

Core Tip: Perivascular epithelioid cell tumors are rare mesenchymal tumors for which the diagnostic criterion appears to be exclusively histopathological. They are characterized by a proliferation of perivascular epithelioid cells and the coexpression of markers for smooth muscle and melanocytes. They mainly affect females and occur in almost all organs. The incidence of benign and malignant perivascular epithelioid cell tumor of the liver is much lower than in other organs. It is necessary to reinforce the notion that there are malignant variants located in the liver, which are more frequently described along with their histologic and immunohistochemical features.