Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2024; 30(16): 2272-2280
Published online Apr 28, 2024. doi: 10.3748/wjg.v30.i16.2272
Optimization of tracheoesophageal fistula model established with T-shaped magnet system based on magnetic compression technique
Miao-Miao Zhang, Jian-Qi Mao, Lin-Xin Shen, Ai-Hua Shi, Xin Lyu, Jia Ma, Yi Lyu, Xiao-Peng Yan
Miao-Miao Zhang, Yi Lyu, Xiao-Peng Yan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Miao-Miao Zhang, Yi Lyu, Xiao-Peng Yan, Shaanxi Provincial Key Laboratory of Magnetic Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Jian-Qi Mao, Lin-Xin Shen, Zonglian College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Ai-Hua Shi, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Xin Lyu, Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Jia Ma, Department of Surgical Oncology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China
Co-first authors: Miao-Miao Zhang and Jian-Qi Mao.
Co-corresponding authors: Xiao-Peng Yan and Yi Lyu.
Author contributions: Lyu Y and Yan XP designed and coordinated the study; Zhang MM, Mao JQ, Shen LX, Lyu X, Ma J, and Yan XP performed the research and acquired the data; Zhang MM, Mao JQ, and Shen LX analyzed the data; Zhang MM and Shi AH tested and analyzed the magnetic force; Zhang MM and Lyu X wrote the manuscript; Yan XP and Lyu Y conceived of the study and contributed to the study design, the interpretation of the results, and the critical revision of the manuscript; and all authors read and approved the final manuscript.
Supported by the Key Research & Development Program of Shaanxi Province of China, No. 2024SF-YBXM-447; Institutional Foundation of The First Affiliated Hospital of Xi’an Jiaotong University, No. 2022MS-07; Fundamental Research Funds for the Central Universities, No. xzy022023068; and Natural Science Foundation of Shaanxi Province, No. 2023-JC-QN-0814.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Experimental Ethics Committee of Xi’an Jiaotong University (Approval No. XJTUAE2023-2207).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that the data supporting the findings of this study are available within the article or from the corresponding authors upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Peng Yan, MD, PhD, Associate Research Scientist, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. yanxiaopeng9966@163.com
Received: January 25, 2024
Revised: March 13, 2024
Accepted: April 8, 2024
Published online: April 28, 2024
Processing time: 92 Days and 0.7 Hours
Core Tip

Core Tip: The magnetic compression technique has been successfully used to establish animal models of tracheoesophageal fistula (TEF) in beagle dogs. However, for TEF, use of the common circular magnet shape is associated with poor homogeneity and poor controllability of model. In this study, we used a modified T-shaped magnet system to establish a TEF, and the results showed this approach could obtain a more stable and uniform fistula size compared with standard magnets. Most importantly, the proposed model offers better controllability, which improves the flexibility of subsequent studies.