Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

doi:10.3748/wjg.v30.i13.1899

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2024; 30(13): 1899-1910
Published online Apr 7, 2024. doi: 10.3748/wjg.v30.i13.1899

Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

Ante Tonkic, Marko Kumric, Ivna Akrapovic Olic, Doris Rusic, Piero Marin Zivkovic, Daniela Supe Domic, Zeljko Sundov, Ivan Males, Josko Bozic

Ante Tonkic, Biology of Neoplasms, University of Split School of Medicine, Split 21000, Croatia

Marko Kumric, Josko Bozic, Department of Pathophysiology, University of Split School of Medicine, Split 21000, Croatia

Ivna Akrapovic Olic, Piero Marin Zivkovic, Zeljko Sundov, Department of Gastroenterology, University Hospital of Split, Split 21000, Croatia

Doris Rusic, Department of Pharmacy, University of Split School of Medicine, Split 21000, Croatia

Daniela Supe Domic, Department of Medical Laboratory Diagnostics, University Hospital of Split, Split 21000, Croatia

Daniela Supe Domic, Department of Health Studies, University of Split, Split 21000, Croatia

Zeljko Sundov, Department of Internal Medicine, University of Split School of Medicine, Split 21000, Croatia

Ivan Males, Department of Surgery, University Hospital of Split, Split 21000, Croatia

Author contributions: Tonkic A participated in conceptualization, methodology, investigation, formal analysis, and original draft preparation; Kumric M participated in visualization, investigation, formal analysis, and original draft preparation; Akrapovic Olic I participated in visualization, investigation, formal analysis, and original draft preparation; Rusic D participated in visualization, investigation, formal analysis, and reviewing and editing of the manuscript; Zivkovic PM participated in visualization, investigation, formal analysis, and original draft preparation; Supe Domic D participated in visualization, investigation, formal analysis, and original draft preparation; Sundov Z participated in visualization, investigation, formal analysis and reviewing, and editing of the manuscript; Males I participated in visualization, investigation, formal analysis, and original draft preparation; Bozic J participated in conceptualization, funding acquisition, resources, project administration, and reviewing and editing of the manuscript; and all authors contributed to the final draft of the manuscript, read and agreed to the published version of the manuscript.

Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the University Hospital of Split (Approval No. 2181-147/01/06/M.S.-21-02).

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrolment.

Conflict-of-interest statement: There are no conflicts of interest to report.

Data sharing statement: No additional data are available.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Josko Bozic, MD, PhD, Associate Professor, Department of Pathophysiology, University of Split School of Medicine, 2 Soltanska, Split 21000, Croatia. josko.bozic@mefst.hr

Received: January 4, 2024
Peer-review started: January 4, 2024
First decision: January 17, 2024
Revised: January 29, 2024
Accepted: March 13, 2024
Article in press: March 13, 2024
Published online: April 7, 2024
Processing time: 89 Days and 15.2 Hours

Core Tip

Core Tip: Serum concentrations of growth-differentiation factor-15 (GDF-15) exhibit a significant elevation in inflammatory bowel disease (IBD) patients compared to healthy controls, irrespective of Crohn’s disease or ulcerative colitis diagnosis. GDF-15 levels independently predict disease severity and demonstrate an association with anemia indices, indicating its potential as a biomarker for IBD pathophysiology. Further exploration is nonetheless warranted to determine the prognostic value of GDF-15 in predicting outcomes for patients with IBD.