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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2024; 30(11): 1488-1493
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1488
Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1488
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
Alessandro Parente, AM James Shapiro, Department of Surgery, Division of Transplantation, University of Alberta Hospital, Edmonton T6G 2B7, Canada
Keyue Sun, Immunity and Inflammation, Lerner Research Institute, Cleveland, OH 44195, United States
Philipp Dutkowski, Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich 8091, Switzerland
Andrea Schlegel, Immunity and Inflammation, Digestive Disease and Surgery Institute, Cleveland, OH 44195, United States
Author contributions: Parente A and Schlegel A designed research; Parente A and Schlegel A wrote the manuscript; Sun K, Shapiro AMJ and Dutkowski P revised the manuscript. All authors approved the final version of the manuscript.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alessandro Parente, FEBS, MD, PhD, Surgeon, Department of Surgery, Division of Transplantation, University of Alberta Hospital, No. 8440 112 St NW, Edmonton T6G 2B7, Canada. aleparen@gmail.com
Received: January 3, 2024
Peer-review started: January 3, 2024
First decision: January 19, 2024
Revised: January 30, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: March 21, 2024
Processing time: 78 Days and 7.1 Hours
Peer-review started: January 3, 2024
First decision: January 19, 2024
Revised: January 30, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: March 21, 2024
Processing time: 78 Days and 7.1 Hours
Core Tip
Core Tip: Machine perfusion (MP) has garnered the interest of the transplant community given its proven beneficial effects on the clinical outcomes after liver transplantation (LT). Herein, we discuss the historical background of MP in LT and the available clinical evidence. Furthermore, we highlighted the obstacles and the need for future research, in particular with respect to viability assessment and prolonged preservation times.