Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China
Jing-Feng Chen, Zhuo-Qing Wu, Hao-Shuang Liu, Su Yan, You-Xiang Wang, Miao Xing, Xiao-Qin Song, Su-Ying Ding
Jing-Feng Chen, Hao-Shuang Liu, Su Yan, Xiao-Qin Song, Su-Ying Ding, Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhuo-Qing Wu, Institute of Systems Engineering, Dalian University of Technology, Dalian 116024, Liaoning Province, China
You-Xiang Wang, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Miao Xing, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Author contributions: Chen JF and Ding SY designed the study and acquired funding; Chen JF and Wu ZQ were responsible for developing the methodology; Yan S and Wang YX participated in the formal analysis and investigation; Chen JF wrote the original draft; Chen JF, Wu ZQ, Liu HS, Yan S, Wang YX, Xing M, Song XQ, and Ding SY participated in the review and editing.
Supported by National Natural Science Foundation of China, No. 72101236; China Postdoctoral Science Foundation, No. 2022M722900; Collaborative Innovation Project of Zhengzhou City, No. XTCX2023006; and Nursing Team Project of the First Affiliated Hospital of Zhengzhou University, No. HLKY2023005.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Zhengzhou University (Approval No. 2020-KY-381).
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Su-Ying Ding, MD, Director, Doctor, Health Management Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Longhu Middle Ring Road, Jinshui District, Zhengzhou 450052, Henan Province, China. fccdingsy@zzu.edu.cn
Received: November 7, 2023
Peer-review started: November 7, 2023
First decision: December 27, 2023
Revised: January 12, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 14, 2024
Processing time: 128 Days and 2.7 Hours
