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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2023; 29(8): 1344-1358
Published online Feb 28, 2023. doi: 10.3748/wjg.v29.i8.1344
Published online Feb 28, 2023. doi: 10.3748/wjg.v29.i8.1344
Establishment of a prediction model for severe acute radiation enteritis associated with cervical cancer radiotherapy
Chen-Ying Ma, Jing Zhao, Guang-Hui Gan, Xiao-Lan He, Xiao-Ting Xu, Song-Bing Qin, Li-Li Wang, Li Li, Ju-Ying Zhou, Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215123, Jiangsu Province, China
Ju-Ying Zhou, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, Jiangsu Province, China
Author contributions: Ma CY and Zhao J contributed to conceptualization and methodology; He XL and Gan GH contributed to data curation; Ma CY contributed to formal analysis; Ma CY, Zhou JY contributed to funding acquisition; Zhou JY, Xu XT, Qin SB contributed to project administration; Zhou JY, Xu XT, Qin SB, Wang LL, and Li L contributed to resources; Xu XT and Qin SB contributed to supervision; Ma CY contributed to validation and visualization; Ma CY and Zhao J contributed to roles/writing-original draft; Ma CY contributed to writing-review and editing.
Supported by the National Natural Science Foundation of China , No. 81602792 and No. 81602802 ; Project of State Key Laboratory of Radiation Medicine and Protection , Soochow University, No. GZK1202101; Suzhou Science and Technology Development Plan Project , No. KJXW2020008; and BOXI Natural Science Cultivation Foundation of China of the First Affiliated Hospital of Soochow University , No. BXQN202107 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital of Soochow University Medical Ethics Committee [approval No. 2016(100)].
Informed consent statement: All enrolled patients provided signed informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets generated and analyzed during the present study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ju-Ying Zhou, MD, Radiation Oncology, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215123, Jiangsu Province, China.
Received: October 17, 2022
Peer-review started: October 17, 2022
First decision: January 3, 2023
Revised: January 13, 2023
Accepted: February 14, 2023
Article in press: February 14, 2023
Published online: February 28, 2023
Processing time: 133 Days and 1.4 Hours
Peer-review started: October 17, 2022
First decision: January 3, 2023
Revised: January 13, 2023
Accepted: February 14, 2023
Article in press: February 14, 2023
Published online: February 28, 2023
Processing time: 133 Days and 1.4 Hours
Core Tip
Core Tip: Radiation enteritis (RE) not only seriously affects the quality of life of patients, but it also leads to radiotherapy intolerance or termination of radiotherapy. The aim of our study was to determine the cumulative incidence of acute RE associated with cervical cancer radiotherapy in patients with RE in organs at risk and changes in dose-volume histogram indices. The nomogram of severe acute RE (SARE) was further developed according to the clinical factors, cumulative incidence of SARE and dosimetric parameters of volumetric modulated arc therapy patients, which may be useful for individualized risk assessment and accurate prediction of SARE to guide clinical treatment strategies.