Systematic Reviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2023; 29(6): 1109-1122
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1109
Relation of COVID-19 with liver diseases and their impact on healthcare systems: The Portuguese case
Sara Fernandes, Milaydis Sosa-Napolskij, Graça Lobo, Isabel Silva
Sara Fernandes, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS-UP), Porto 4050-313, Portugal
Milaydis Sosa-Napolskij, CINTESIS@RISE, Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research Network, Faculty of Medicine of The University of Porto, Porto 4200-219, Portugal
Graça Lobo, Isabel Silva, Laboratory of Pharmacology and Neurobiology–Department of Immuno-physiology and Pharmacology, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS-UP), Porto 4050-313, Portugal
Graça Lobo, Isabel Silva, Center for Drug Discovery and Innovative Medicines (MedInUP), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS-UP), Porto 4050-313, Portugal
Author contributions: Fernandes S and Sosa-Napolskij M contributed equally to this work; Fernandes S, Sosa-Napolskij M, Lobo G, and Silva I designed the research study, performed the research, analyzed the data, and wrote the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Isabel Silva, Doctor, PhD, Researcher, Laboratory of Pharmacology and Neurobiology–Department of Immuno-physiology and Pharmacology, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, nº228, Porto 4050-313, Portugal. isabel.silva@ibmc.up.pt
Received: September 13, 2022
Peer-review started: September 13, 2022
First decision: November 5, 2022
Revised: November 18, 2022
Accepted: December 30, 2022
Article in press: December 30, 2022
Published online: February 14, 2023
Processing time: 149 Days and 12.6 Hours
Core Tip

Core Tip: This review analyzes how the coronavirus disease 2019 (COVID-19) affects health care and clinical practice in Portugal and the possible causes of liver injury in COVID-19 individuals, including the direct effect of severe acute respiratory syndrome coronavirus 2 on the liver and drug-induced liver injury, and how preexisting liver diseases affect the treatment of COVID-19.