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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2023; 29(5): 867-878
Published online Feb 7, 2023. doi: 10.3748/wjg.v29.i5.867
Published online Feb 7, 2023. doi: 10.3748/wjg.v29.i5.867
Impact of endothelial nitric oxide synthase activation on accelerated liver regeneration in a rat ALPPS model
Hitoshi Masuo, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Takahiro Yoshizawa, Kiyotaka Hosoda, Koya Yasukawa, Akira Kobayashi, Yuji Soejima, Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Author contributions: Masuo H, Motoyama H, Yoshizawa T, Hosoda K, and Yasukawa K contributed to the acquisition and analysis of experimental data and drafting of the manuscript; Shimizu A, Kubota K, Notake T, Kobayashi A, and Soejima Y contributed to the conception and design of the study and made critical revisions related to the important intellectual content of the manuscript; and all authors have provided final approval for the version of the manuscript for submission.
Supported by the JSPS KAKENHI , JP17K10664.
Institutional animal care and use committee statement: Based on national and institutional regulations and guidelines, all procedures for animal experiments were reviewed by the Committee for Animal Experiments and approved by the President of Shinshu University (Approval numbers 270018 and 019067).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akira Shimizu, MD, PhD, Associate Professor, Division of Gastroen
Received: October 29, 2022
Peer-review started: October 29, 2022
First decision: November 30, 2022
Revised: December 7, 2022
Accepted: January 11, 2023
Article in press: January 11, 2023
Published online: February 7, 2023
Processing time: 94 Days and 5.4 Hours
Peer-review started: October 29, 2022
First decision: November 30, 2022
Revised: December 7, 2022
Accepted: January 11, 2023
Article in press: January 11, 2023
Published online: February 7, 2023
Processing time: 94 Days and 5.4 Hours
Core Tip
Core Tip: In extended hepatectomy for hepatobiliary tumors, adequate future liver remnant (FLR) is essential to prevent postoperative liver failure. Portal vein embolization (PVE) and associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) are performed to increase the FLR. Although ALPPS induces more rapid liver regeneration than PVE, the mechanism remains unclear. In this study, we compared ALPPS with portal vein ligation (PVL) in a rat model and found that activation of the Akt-endothelial nitric oxide synthase pathway promotes liver regeneration. The combination of PVL and nitric oxide-producing agents may induce liver regeneration comparable to ALPPS in a non-invasive manner.