Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea

doi:10.3748/wjg.v29.i44.5882

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 28, 2023; 29(44): 5882-5893
Published online Nov 28, 2023. doi: 10.3748/wjg.v29.i44.5882

Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea

Yoon Jin Choi, Tae Jun Kim, Chang Seok Bang, Yong Kang Lee, Moon Won Lee, Su Youn Nam, Woon Geon Shin, Seung In Seo

Yoon Jin Choi, Department of Internal Medicine, National Cancer Center, Goyang-si 13620, South Korea

Tae Jun Kim, Department of Internal Medicine, Samsung Medical Center, Seoul 06351, South Korea

Chang Seok Bang, Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Chuncheon 24253, South Korea

Yong Kang Lee, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si 10444, South Korea

Moon Won Lee, Department of Internal Medicine, Pusan National University School of Medicine, Busan 50463, South Korea

Su Youn Nam, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Chilgok Hospital, Daegu 41404, South Korea

Woon Geon Shin, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, South Korea

Woon Geon Shin, Seung In Seo, Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24253, South Korea

Seung In Seo, Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul 05355, South Korea

Author contributions: Choi YJ and Seo SI contributed to the acquisition of data, analysis and interpretation of data, drafting of the manuscript; Kim TJ, Bang CS, Lee YK, and Lee MW participated in the technical or material support of this study; Nam SY and Shin WG contributed to the critical revision of the manuscript for important intellectual content; Seo SI involved in the study concept and design, and study supervision.

Institutional review board statement: This study was approved by the Institutional Review Board (IRB) of Kangdong Sacred Hospital (IRB number: 2021-11-001). The other six hospitals were affiliated with the Research Border Free Zone, which recognizes IRB approval of the research organizing center and waives individual IRB approval.

Informed consent statement: As the study used anonymous and pre-existing data, the requirement for the informed consent from patients was waived.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: Dataset available from the corresponding author’s e-mail doctorssi@kdh.or.kr.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Seung In Seo, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, 150, Seongan-ro, Gangdong-gu, Seoul 05355, South Korea. doctorssi@kdh.or.kr

Received: June 5, 2023
Peer-review started: June 5, 2023
First decision: August 26, 2023
Revised: September 30, 2023
Accepted: November 14, 2023
Article in press: November 14, 2023
Published online: November 28, 2023

Core Tip

Core Tip: In the multicenter study including 26785 peptic ulcer disease (PUD) patients from 7 databases, the overall number of PUD exhibited no decrease, whereas PUD in old age revealed an increasing trend from 2010 to 2019 in Korea. According to etiology, decreasing trend of Helicobacter pylori-related PUD after year 2014, and increasing trend of drug-related PUD were observed in the past decade. Drug-related PUD showed significantly more comorbidities and exposure to concomitant ulcerogenic drugs, and the idiopathic PUD group had a significantly higher proportion in the chronic liver disease. Further studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.