Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2023; 29(43): 5834-5847
Published online Nov 21, 2023. doi: 10.3748/wjg.v29.i43.5834
Helicobacter pylori infection in Xinjiang Uyghur Autonomous Region: Prevalence and analysis of related factors
Yu-Hua Peng, Xue Feng, Zhong Zhou, Lei Yang, Yun-Fei Shi
Yu-Hua Peng, Zhong Zhou, Department of Pathology, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, The Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Xue Feng, Department of Laboratory Medicine, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region, The Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Lei Yang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing Office for Cancer Prevention and Control, Peking University Cancer Hospital & Institute, Beijing 100142, China
Yun-Fei Shi, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China
Co-first authors: Yu-Hua Peng and Xue Feng.
Author contributions: Peng YH and Feng X collected samples and clinicopathological data, participated in the data analysis and drafted the manuscript; Zhou Z finished the pathological experimental procedures; Yang L performed the statistical analysis; Shi YF designed and supervised the study, revised the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: The study was approved by the Science and Research Office of Traditional Chinese Medical Hospital of Xinjiang Medical University (Urumqi).
Informed consent statement: As a pure retrospective study, and no intervention and impacts on the diagnosis and treatment of the patients involved, informed consent in our study was waived as approved by the Ethics Committee of the hospital.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Fei Shi, MD, PhD, Doctor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. shiyunfei@bjmu.edu.cn
Received: August 19, 2023
Peer-review started: August 19, 2023
First decision: September 28, 2023
Revised: October 10, 2023
Accepted: October 29, 2023
Article in press: October 29, 2023
Published online: November 21, 2023
Core Tip

Core Tip: The sensitivity of 14C urea breath test (14C UBT) for detecting Helicobacter pylori (H. pylori) is significantly higher than that of immunohistochemistry (IHC) with endoscopy specimens. Combination of 14C UBT and IHC is necessary to improve detection accuracy, and increasing the number of biopsy specimens (≥ 2) can improve the positive rate significantly. The overall rate of H. pylori infection in Xinjiang Uyghur Autonomous Region was higher than in previous studies. H. pylori infection was more prevalent in the Uyghur population and the infection rate decreased as age increased. Therefore, the prevention and intervention of H. pylori infection in Xinjiang Uyghur Autonomous Region should emphasize Uyghur and young people.