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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2023; 29(39): 5435-5451
Published online Oct 21, 2023. doi: 10.3748/wjg.v29.i39.5435
Published online Oct 21, 2023. doi: 10.3748/wjg.v29.i39.5435
Function and biomedical implications of exosomal microRNAs delivered by parenchymal and nonparenchymal cells in hepatocellular carcinoma
Hai-Chen Wang, Wen-Xuan Yin, Meng Jiang, Jia-Yi Han, Xing-Wang Kuai, Rui Sun, Yu-Feng Sun, Ju-Ling Ji, Department of Pathology, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Meng Jiang, Jia-Yi Han, Xing-Wang Kuai, Rui Sun, Yu-Feng Sun, Ju-Ling Ji, Key Laboratory of Microenvironment and Translational Cancer Research, Science and Technology Bureau of Nantong City, Nantong 226001, Jiangsu Province, China
Ju-Ling Ji, Department of Pathology, The Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Ji JL designed the review; Wang HC and Ji JL drafted the paper; Wang HC prepared the figure; Yin WX, Jiang M, Han JY, and Sun YF researched the background of the study; Ji JL, Kuai XW, and Sun R reviewed and revised the paper; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China , No. 81761128018 and No. 81572871 ; the Natural Science Foundation of Jiangsu Province , No. BK20151277 ; and the Undergraduate Training Programs for Innovation and Entrepreneurship of Jiangsu Province , No. 202110304035Z .
Conflict-of-interest statement: The authors declare having no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ju-Ling Ji, MD, PhD, Professor, Department of Pathology, Medical School of Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. jijuling@ntu.edu.cn
Received: May 26, 2023
Peer-review started: May 26, 2023
First decision: July 23, 2023
Revised: August 13, 2023
Accepted: October 16, 2023
Article in press: October 16, 2023
Published online: October 21, 2023
Peer-review started: May 26, 2023
First decision: July 23, 2023
Revised: August 13, 2023
Accepted: October 16, 2023
Article in press: October 16, 2023
Published online: October 21, 2023
Core Tip
Core Tip: Hepatocellular carcinoma (HCC) is one of the most serious cancers in adults, and microRNAs (miRNAs) in small extracellular vesicles (exosomes) play a vital role in the pathological processes of HCC. Recent studies on exosomal miRNAs in HCC mainly focus on miRNA profiling but place little emphasis on where miRNAs come from and what target cells they act on. This review focused on the origin of exosomal miRNAs according to their parent cells in the tumor microenvironment and their role in HCC pathogenesis, contributing to a better understanding of exosomal miRNAs in the tumor microenvironment.