Minireviews
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World J Gastroenterol. Oct 7, 2023; 29(37): 5305-5312
Published online Oct 7, 2023. doi: 10.3748/wjg.v29.i37.5305
Sequence of events leading to primary biliary cholangitis
Ilaria Lenci, Paola Carnì, Martina Milana, Agreta Bicaj, Alessandro Signorello, Leonardo Baiocchi
Ilaria Lenci, Paola Carnì, Martina Milana, Agreta Bicaj, Alessandro Signorello, Leonardo Baiocchi, Hepatology Unit, University of Tor Vergata, Rome 00133, Italy
Paola Carnì, Agreta Bicaj, Leonardo Baiocchi, Postgraduate School in Hepato/Gastroenterology, Catholic University Our Lady of Good Counsel, Tirana 1004, Albania
Author contributions: Lenci I acquisition of data, analysis and interpretation, drafting of manuscript, critical revision; Carnì P, Milana M, Bicaj A, and Signorello A acquisition of data, critical revision; Baiocchi L proposal of study, study conception, correction of manuscript, critical revision.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Leonardo Baiocchi, MD, PhD, Associate Professor, Senior Scientist, Hepatology Unit, University of Tor Vergata, No. 81 Viale Oxford, Rome 00133, Italy. baiocchi@uniroma2.it
Received: July 7, 2023
Peer-review started: July 7, 2023
First decision: August 15, 2023
Revised: August 22, 2023
Accepted: September 11, 2023
Article in press: September 11, 2023
Published online: October 7, 2023
Processing time: 79 Days and 18.4 Hours
Core Tip

Core Tip: Primary biliary cholangitis is a chronic cholestatic human disease. The pathological processes that favor the evolution toward end-stage liver disease during this disorder are only partially elucidated. The aim of this minireview is to summarize the sequential pathological contributors, supporting the progression of liver injury, in the course of this disease.