Lowering the threshold of alanine aminotransferase for enhanced identification of significant hepatic injury in chronic hepatitis B patients
Hong-Sheng Yu, Hao Jiang, Ming-Kai Li, Bi-Lan Yang, Abdukyamu Smayi, Bin Wu, Yi-Dong Yang, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Hong-Sheng Yu, Hao Jiang, Ming-Kai Li, Bi-Lan Yang, Abdukyamu Smayi, Bin Wu, Yi-Dong Yang, Department of Liver Disease, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou 510630, Guangdong Province, China
Jian-Ning Chen, Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Yu HS and Jiang H have contributed equally to this work; Yu HS and Jiang H designed the study, performed the statistical analysis, and drafted the manuscript; Li MK, Yang BL, Smayi A and Chen JN collected the clinical data and then reviewed the data; Wu B and Yang YD revised the manuscript; Yang YD and Wu B were responsible for the study conception, design, data, analysis; All authors have read and approved the manuscript.
Supported by The Natural Science Foundation of Guangdong Province for Distinguished Young Scholar, No. 2022B1515020024; National Natural Science Foundation of China, No. 82070574; and The Natural Science Foundation Team Project of Guangdong Province, No. 2018B030312009.
Institutional review board statement: The study was reviewed and approved by the Third Affiliated Hospital of Sun Yat-Sen University. No. 02-530-01.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Dong Yang, PhD, Associate Professor, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. firstname.lastname@example.org
Received: July 2, 2023
Peer-review started: July 2, 2023
First decision: July 14, 2023
Revised: July 22, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: September 21, 2023