Randomized Controlled Trial
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2023; 29(31): 4783-4796
Published online Aug 21, 2023. doi: 10.3748/wjg.v29.i31.4783
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
Fu-Wei Zhang, Xiao-Wei Xie, Meng-Hua Chen, Jian Tong, Qun-Qing Chen, Jing Feng, Feng-Ti Chen, Wen-Qi Liu
Fu-Wei Zhang, Jian Tong, Qun-Qing Chen, Jing Feng, Department of Thoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China
Xiao-Wei Xie, Meng-Hua Chen, Feng-Ti Chen, Wen-Qi Liu, Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhang FW and Liu WQ contributed to the conceptualization of this manuscript; Tong J, Chen QQ, and Feng J collected and curated the data and contributed to the supervision of this study; Xie XW contributed to the experiments; Tong J contributed to the data analysis; Zhang FW wrote the original draft; Liu WQ contributed to the writing, review and editing of this article; and all authors reviewed, discussed, and agreed with manuscript.
Institutional review board statement: The study was reviewed and approved by the Second Affiliated Hospital of Guangxi Medical University Ethics Committee.
Clinical trial registration statement: Our study was not a prospective, randomized, controlled clinical trial and did not give a population one or more pre-defined interventions. Our study was a retrospective study of postoperative tissue samples from patients who had completed treatment. Cell experiments and animal experiments were conducted according to the results of clinical specimens. Therefore, our study should not apply the registration policy and should not require registration for clinical studies.
Informed consent statement: Written patient consent was obtained from all patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Qi Liu, PhD, Chief Doctor, Doctor, Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 East University Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. liuwenqigx@163.com
Received: April 4, 2023
Peer-review started: April 4, 2023
First decision: April 12, 2023
Revised: April 29, 2023
Accepted: July 27, 2023
Article in press: July 27, 2023
Published online: August 21, 2023
Processing time: 136 Days and 5.5 Hours
Core Tip

Core Tip: Bioinformatics analysis showed that the expression of the poly(A)-specific ribonuclease (PARN) gene in gastric cancer, head and neck squamous cell carcinoma, melanoma, cervical cancer and lung squamous cell carcinoma tissues was significantly higher than that in normal tissues and was associated with high stage and poor prognosis. The expression of the PARN gene in esophageal cancer (EC) tissue is also significantly higher than that in normal tissues, but the effect of PARN on the proliferation, migration and invasion of EC cells remains unclear. This study investigated the relationship between PARN and the proliferation, migration and invasion of EC cells.