Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2023; 29(29): 4499-4527
Published online Aug 7, 2023. doi: 10.3748/wjg.v29.i29.4499
Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly
Yu-De Chu, Chun-Wei Chen, Ming-Wei Lai, Siew-Na Lim, Wey-Ran Lin
Yu-De Chu, Liver Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Chun-Wei Chen, Wey-Ran Lin, Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Ming-Wei Lai, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Siew-Na Lim, Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Wey-Ran Lin, Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Author contributions: Chu YD and Chen CW contributed equally to this article; Chu YD and Chen CW wrote the draft of the manuscript; Lai MW and Lim SN collected the data; Lin WR reviewed and edited the manuscript.
Supported by Ministry of Science and Technology, Taiwan, No. MOST-110-2314-B-182A-095- and No. MOST-111-2314-B-182A-126- (to Lin WR); and Chang Gung Memorial Hospital, Linkou Branch, Taiwan, No. CMRPG3K2292, No. CMRPG3J0693 (to Lin WR), No. CORPG3J0531, No. CORPG3L0261, No. CORPG3J0501, and No. CMRPG3K0771 (to Chen CW).
Conflict-of-interest statement: The authors declare no conflicts of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wey-Ran Lin, AGAF, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, No. 5 Fu-Shin Street, Taoyuan 333, Taiwan. t12360@adm.cgmh.org.tw
Received: March 28, 2023
Peer-review started: March 28, 2023
First decision: May 12, 2023
Revised: May 23, 2023
Accepted: July 3, 2023
Article in press: July 3, 2023
Published online: August 7, 2023
Processing time: 126 Days and 9.6 Hours
Core Tip

Core Tip: This review discusses the bioenergetic alteration and metabolic reprogramming in gastrointestinal (GI) cancers, including the interplay between aerobic glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation. The review also highlights potential strategies for targeting bioenergetic regulators for anti-cancer therapy in GI cancers, summarizing the efficacy and challenges of several drugs.