Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2023; 29(28): 4466-4480
Published online Jul 28, 2023. doi: 10.3748/wjg.v29.i28.4466
One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability: A systematic review and meta-analysis
Mahmoud Obeidat, Brigitta Teutsch, Anett Rancz, Edina Tari, Katalin Márta, Dániel Sándor Veres, Nóra Hosszúfalusi, Emese Mihály, Péter Hegyi, Bálint Erőss
Mahmoud Obeidat, Brigitta Teutsch, Anett Rancz, Edina Tari, Katalin Márta, Dániel Sándor Veres, Nóra Hosszúfalusi, Emese Mihály, Péter Hegyi, Bálint Erőss, Centre for Translational Medicine, Semmelweis University, Budapest 1085, Hungary
Mahmoud Obeidat, Brigitta Teutsch, Péter Hegyi, Bálint Erőss, Institute for Translational Medicine, Medical School, University of Pécs, Pécs 7623, Hungary
Anett Rancz, Nóra Hosszúfalusi, Emese Mihály, Department of Internal Medicine and Hematology, Semmelweis University, Faculty of Medicine, Budapest 1085, Hungary
Edina Tari, Katalin Márta, Péter Hegyi, Bálint Erőss, Institute of Pancreatic Diseases, Semmelweis University, Budapest 1083, Hungary
Dániel Sándor Veres, Department of Biophysics and Radiation Biology, Semmelweis University, Budapest 1085, Hungary
Author contributions: Obeidat M contributed to conceptualization, investigation, project administration, visualization, validation, writing – original draft; Teutsch B contributed to conceptualization, methodology, project administration, validation, writing – review & editing; Rancz A contributed to conceptualization, investigation, writing – review & editing; Tari E: conceptualization, investigation, writing – review & editing; Márta K contributed to conceptualization, writing – review & editing; Veres DS contributed to conceptualization, formal analysis, software, writing – review & editing; Hosszúfalusi N contributed to conceptualization, writing – review & editing; Mihály E contributed to conceptualization, writing – review & editing; Hegyi P contributed to conceptualization, writing – review & editing; Erőss B contributed to conceptualization, supervision, validation, writing – review & editing; All authors certify that they have participated sufficiently in the work to take public responsibility for the content, including participation in the concept, design, analysis, writing, or revision of the manuscript.
Supported by The Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund (ITM-NRDIF), No. TKP2021-EGA-23.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: All authors have read the PRISMA 2020 checklist, and the manuscript was prepared and revised according to the PRISMA 2020 checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bálint Erőss, MD, PhD, Assistant Professor, Doctor, Centre for Translational Medicine, Semmelweis University, Üllői street 26, Budapest 1085, Hungary. dr.eross.balint@gmail.com
Received: February 10, 2023
Peer-review started: February 10, 2023
First decision: May 16, 2023
Revised: May 30, 2023
Accepted: June 14, 2023
Article in press: June 14, 2023
Published online: July 28, 2023
Processing time: 165 Days and 18.1 Hours
Core Tip

Core Tip: Gastrointestinal bleeding is one of the most common gastrointestinal emergencies with estimated mortality up to 10%. It is associated with significant morbidity, additional burden, and health care costs. It is documented that hemodynamic instability and shock are highly associated with untoward outcomes; they lead to a higher mortality rate, rebleeding risk, prehospital transfusion, and sedation complications. Our study provides clear evidence that hemodynamic instability and shock are common presentations and complications in gastrointestinal bleeding and gives insight into some possible predictor factors.