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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2023; 29(26): 4200-4213
Published online Jul 14, 2023. doi: 10.3748/wjg.v29.i26.4200
Published online Jul 14, 2023. doi: 10.3748/wjg.v29.i26.4200
Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor
Wen-Zhi Qu, Yang Wang, Department of General Surgery, The 4th Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Luan Wang, Department of Emergency, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Juan-Juan Chen, Department of Medical Service, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang Y designed research; Wang Y, Wang L and Qu WZ performed research; Wang Y and Qu WZ analyzed data; Wang Y, Chen JJ and Wang L wrote the paper; Wang Y edited the paper and provided primary revised opinion; All authors have read and approve the final manuscript.
Supported by Natural Science Foundation of Liaoning Province , No.2020-MS-148 .
Institutional review board statement: The study was reviewed and approved by the 4th Affiliated Hospital of China Medical University’s Institutional Review Board, No. EC-2020-KS-015.
Informed consent statement: Consent was not obtained but the presented data are anonymized, and risk of identification is low. With the approval of the ethics committee, informed consent was waived.
Conflict-of-interest statement: The authors report grants from Natural Science Foundation of Liaoning Province, China, during the conduct of the study. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted and entitled 'Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor'.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wwyy840731@126.com. Consent was not obtained but the presented data are anonymized, and risk of identification is low. No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Wang, MD, PhD, Associate Professor, Doctor, Department of General Surgery, The 4th Affiliated Hospital of China Medical University, No. 4 Chongshan Road, Huanggu District, Shenyang 110032, Liaoning Province, China. wwyy840731@126.com
Received: April 24, 2023
Peer-review started: April 24, 2023
First decision: May 16, 2023
Revised: May 20, 2023
Accepted: June 2, 2023
Article in press: June 2, 2023
Published online: July 14, 2023
Processing time: 77 Days and 1 Hours
Peer-review started: April 24, 2023
First decision: May 16, 2023
Revised: May 20, 2023
Accepted: June 2, 2023
Article in press: June 2, 2023
Published online: July 14, 2023
Processing time: 77 Days and 1 Hours
Core Tip
Core Tip: Nowadays, research reports on the expression of downstream proteins of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway combined with raf kinase inhibitor protein (RKIP) in gastrointestinal stromal tumor (GIST) is scarce. This study will focus on this aspect and use immunohistochemistry methods, large sample survival analysis data, and the latest bioinformatics analysis techniques to answer the problem. Our experimental results showed that the expression of the two proteins had a certain negative correlation. The combined expression of RKIP and phosphorylated-ERK proteins can serve as an independent risk factor for predicting the prognosis of GIST patients. Furthermore, the new risk assessment model incorporating RKIP and phosphorylated-ERK has superior evaluation efficacy.