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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2023; 29(21): 3222-3240
Published online Jun 7, 2023. doi: 10.3748/wjg.v29.i21.3222
Published online Jun 7, 2023. doi: 10.3748/wjg.v29.i21.3222
Crohn’s disease: Why the ileum?
Nicolas Richard, Guillaume Savoye, Mathilde Leboutte, Rachel Marion-Letellier, University of Rouen Normandie, INSERM, ADEN UMR 1073, Nutrition, Inflammation and Microbiota-Gut-Brain Axis, Rouen F-76000, France
Nicolas Richard, Guillaume Savoye, CHU Rouen, Department of Gastroenterology, Rouen University Hospital-Charles Nicolle, Rouen F-76000, France
Nicolas Richard, Guillaume Savoye, Mathilde Leboutte, Rachel Marion-Letellier, Institute for Research and Innovation in Biomedicine, University of Rouen Normandie, Rouen F-76000, France
Asma Amamou, Subrata Ghosh, APC Microbiome Ireland, Biosciences Building, University College Cork, Cork T12 YT20, Ireland
Author contributions: Richard N wrote the first draft; all authors have read and approve the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rachel Marion-Letellier, PhD, Associate Professor, University of Rouen Normandie, INSERM, ADEN UMR 1073, Nutrition, Inflammation and Microbiota-Gut-Brain Axis, 22 Boulevard Gambetta, Rouen F-76000, France. rachel.letellier@univ-rouen.fr
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: January 10, 2023
Revised: January 23, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 7, 2023
Peer-review started: December 28, 2022
First decision: January 10, 2023
Revised: January 23, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 7, 2023
Core Tip
Core Tip: The ileum is most frequently affected by Crohn’s disease (CD). Ileal CD differs from other CD types in its epidemiology and natural history. Anatomical and histological features of the ileum provide the keys to understanding this distinct phenotype. Moreover, we discuss herein the crosstalk that occurs in the ileum between an individual and her/his environment and the clinical significance.