Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2023; 29(19): 2961-2978
Published online May 21, 2023. doi: 10.3748/wjg.v29.i19.2961
MMP14 is a diagnostic gene of intrahepatic cholangiocarcinoma associated with immune cell infiltration
Jun Wu, Yang Guo, Zhi-Fan Zuo, Zi-Wei Zhu, Lei Han
Jun Wu, Zi-Wei Zhu, China Medical University, The General Hospital of Northern Theater Command Training Base for Graduate, Shenyang 110016, Liaoning Province, China
Yang Guo, Lei Han, Department of Hepatobiliary Surgery, The General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
Zhi-Fan Zuo, Gynecological Radiotherapy Ward, Liaoning Provincial Cancer Hospital, Shenyang 110801, Liaoning province, China
Author contributions: Han L conceived and directed the entire study, and should be regarded as corresponding author; Wu J and Guo Y designed the study and prepared the manuscript; Zuo ZF defined the intellectual content of the study and participated in the literature research; Wu J, Guo Y, and Zuo ZF contributed equally to this study; Zhu ZW conducted data analysis; Han L and Wu J revised the manuscript; and all authors approved to submit the manuscript.
Institutional review board statement: This study is not involved any human and animal.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The bioinformatic data could be downloaded from the public databases, and no additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Han, MD, Associate Chief Physician, Deputy Director, Department of Hepatobiliary Surgery, The General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. hanlei1974@sina.com
Received: February 28, 2023
Peer-review started: February 28, 2023
First decision: March 14, 2023
Revised: March 24, 2023
Accepted: April 23, 2023
Article in press: April 23, 2023
Published online: May 21, 2023
Processing time: 76 Days and 24 Hours
Core Tip

Core Tip: This study demonstrates that a new candidate molecular marker: MMP14 that is important for the diagnosis of intrahepatic cholangiocarcinoma, and MMP14 was related to a variety of immune cell components and participated in the occurrence and development in intrahepatic cholangiocarcinoma.