Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2023; 29(18): 2798-2817
Published online May 14, 2023. doi: 10.3748/wjg.v29.i18.2798
Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways
Liu Shi, Li Zhou, Ming Han, Yu Zhang, Yang Zhang, Xiao-Xue Yuan, Hong-Ping Lu, Yun Wang, Xue-Liang Yang, Chen Liu, Jun Wang, Pu Liang, Shun-Ai Liu, Xiao-Jing Liu, Jun Cheng, Shu-Mei Lin
Liu Shi, Xiao-Jing Liu, Shu-Mei Lin, Department of Infectious Disease Medicine, The First Hospital Affiliated to Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Li Zhou, China-Japan Friendship Hospital, Department of Infectious Disease China-Japan Friendship Hospital, Beijing 100029, China
Ming Han, Yang Zhang, Xiao-Xue Yuan, Chen Liu, Pu Liang, Shun-Ai Liu, Jun Cheng, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Yu Zhang, Yun Wang, The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Hong-Ping Lu, Institute of Liver Diseases, Beijing Pan-Asia Tongze Institute of Biomedicine Co., Ltd, Beijing 100015, China
Xue-Liang Yang, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Jun Wang, Beijing Key Laboratory of Emerging Infectious Diseases, Peking University Ditan Teaching Hospital, Beijing 100015, China
Author contributions: Shi L, Zhou L, Han M, Zhang Y, Zhang Y, Yuan XX, Lu HP, Wang Y, Yang XL, Liu C, Wang J, Liang P, Liu SA, Liu XJ, Cheng J, and Lin SM contributed to the study conception and design; Liu S, Li Z, Ming H, Yu Z, Yang Z, Xue YX, Ping LH, Yun W, Liang YX, Chen L, Jun W, and Jing LX participated in the design and completion of the experiment; Liu S wrote the original draft; Liu S, Jun C, and Mei LS reviewed and edited the manuscript; Pu L and Ai LS finished the project administration; Jun C and Mei LS have the same contribution to the article; all authors approved the final version of the article.
Supported by the National Key Research and Development Program of China, No. 2017YFC0908104; and National Science and Technology Projects, No. 2017ZX10203201, No. 2017ZX10201201, and No. 2017ZX10202202.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee at Xi’an Jiaotong University Medical Science Center (approval No. 2020-1739).
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Mei Lin, Doctor, MD, PhD, Doctor, Professor, Teacher, Department of Infectious Disease Medicine, The First Hospital Affiliated to Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta, Xi’an 710061, Shaanxi Province, China. lsmxjtu@126.com
Received: December 13, 2022
Peer-review started: December 13, 2022
First decision: February 23, 2023
Revised: March 8, 2023
Accepted: April 10, 2023
Article in press: April 10, 2023
Published online: May 14, 2023
Processing time: 148 Days and 21.6 Hours
Core Tip

Core Tip: We proved that hepatitis C virus nonstructural protein 3-transactivated protein 1 (NS3TP1) promoted hepatic fibrosis via the transforming growth factor beta 1/Smad3 and NF-κB signaling pathways. Calcitriol attenuates liver fibrosis through NS3TP1-mediated above both signaling pathways. These novel findings profoundly expand our knowledge about the mechanisms underlying the role and function of NS3TP1 in hepatic fibrosis. The relationship between NS3TP1 and liver fibrosis was discussed for the first time and provided a foundation for research related to liver fibrosis by targeting NS3TP1. We first showed that calcitriol alleviated hepatic fibrosis through the above signaling pathways via NS3TP1.