Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2023; 29(18): 2733-2746
Published online May 14, 2023. doi: 10.3748/wjg.v29.i18.2733
Study of tumor necrosis factor receptor in the inflammatory bowel disease
Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Henrique Inhauser Riceti Magalhães, Patricia Castelucci
Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Patricia Castelucci, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
Henrique Inhauser Riceti Magalhães, Department of Surgery, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-270, Brazil
Author contributions: Souza RF, Caetano MAF and Magalhães HIR were responsible for the literature review, and analysis and written; Castelucci P performed the critical interpretation and revised the manuscript for intellectual content; all authors have read and approved the final manuscript.
Supported by Research Support Foundation of the State of São Paulo (FAPESP, Brazil), No. 2014/25927-2, No. 2018/07862-1; National Council for Scientific and Technological Development (CNPq, Brazil); and Higher Education Personnel Improvement Coordination (CAPES, Brazil).
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Patricia Castelucci, MHSc, PhD, Associate Professor, Associate Research Scientist, Lecturer, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Av. Dr. Lineu Prestes, 2415, São Paulo 05508-000, Brazil.
Received: December 30, 2022
Peer-review started: December 30, 2022
First decision: January 22, 2023
Revised: February 14, 2023
Accepted: April 4, 2023
Article in press: April 4, 2023
Published online: May 14, 2023
Core Tip

Core Tip: This review summarizes the role of Tumor Necrosis Factor-alpha (TNF-α) in promoting inflammation. Studies have suggested that TNF-α is one of the main pro-inflammatory cytokines involved in the pathogenesis of Inflammatory Bowel Diseases (IBD). In addition, the enteric nervous system is affected by IBD. There are two receptors for TNF: The tumor necrosis factor 1 receptor; and the tumor necrosis factor 2 receptor. They are involved in the pathogenesis of IBD. The application of antibodies aimed at neutralizing TNF-α in patients with IBD induce a satisfactory clinical recovery. This review addresses the main aspects of TNF-α in IBD and anti-TNF therapies.