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World J Gastroenterol. May 14, 2023; 29(18): 2704-2716
Published online May 14, 2023. doi: 10.3748/wjg.v29.i18.2704
Key elements determining the intestinal region-specific environment of enteric neurons in type 1 diabetes
Mária Bagyánszki, Nikolett Bódi
Mária Bagyánszki, Nikolett Bódi, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary
Author contributions: Bagyánszki M and Bódi N wrote the original draft, they also wrote the review and editing, performed the visualization; all the authors have read and approve the final manuscript.
Supported by Hungarian NKFIH Fund Project (N.B.), No. FK131789; János Bolyai Research Scholarship of The Hungarian Academy of Sciences (N.B.); and New National Excellence Program of The Ministry for Innovation and Technology from The Source of The National Research, Development and Innovation Fund (N.B.); No. ÚNKP-22-5.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép Fasor 52, Szeged H-6726, Hungary.
Received: December 15, 2022
Peer-review started: December 15, 2022
First decision: March 15, 2023
Revised: March 28, 2023
Accepted: April 17, 2023
Article in press: April 17, 2023
Published online: May 14, 2023
Core Tip

Core Tip: Diabetes-related intestinal motility disturbances result from multifactorial damage to the enteric nervous system. However, the diversity of the neuronal environment in different gut segments basically determines the regionality of diabetic enteric neuropathy. Therefore, in this review, we highlight the role of enteric glial cells, gut circulation, intestinal epithelium, gut microbiota, immune and enteroendocrine cells, pro-oxidants, antioxidant defence and extracellular matrix, which have great impact on the formation and maintenance of a region-specific enteric neuronal environment in diabetes.