Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2023; 29(17): 2628-2641
Published online May 7, 2023. doi: 10.3748/wjg.v29.i17.2628
Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model
Gabrielle Caroline Peiter, Thayene Kamyli Moesch Queiroz, Edson Luiz Michalkiewicz Jr, Raphael Henrique Chappuis, Jennefer Sousa Luz, Luiz Henrique Casagrande Piovezani, Cleison Ferreira Silva, Matheus Nozomi Tsutumi, Augusto Fernandes Chaves, Rafael Messias Luiz, Cinthia Façanha Wendel, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira
Gabrielle Caroline Peiter, Kádima Nayara Teixeira, Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular - Setor Palotina, Universidade Federal do Paraná, Palotina 85.950-000, Paraná, Brazil
Thayene Kamyli Moesch Queiroz, Ana Carla Zarpelon-Schutz, Programa de Pós-graduação em Biotecnologia - Setor Palotina, Universidade Federal do Paraná, Palotina 85.950-000, Paraná, Brazil
Edson Luiz Michalkiewicz Jr, Raphael Henrique Chappuis, Jennefer Sousa Luz, Luiz Henrique Casagrande Piovezani, Cleison Ferreira Silva, Matheus Nozomi Tsutumi, Augusto Fernandes Chaves, Rafael Messias Luiz, Cinthia Façanha Wendel, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira, Campus Toledo, Universidade Federal do Paraná, Toledo 85.919-899, Paraná, Brazil
Author contributions: Peiter GC, Moesch Queiroz TK, Michalkiewicz Jr EL, Chappuis RH, Luz JS, Casagrande Piovezani LH, Ferreira Silva C, Nozomi Tsutumi M, Fernandes Chaves A, Luiz RM and Façanha Wendel C performed the experiments; Zarpelon-Schutz AC, Peiter GC and Teixeira KN analyzed the results and wrote the manuscript; Zarpelon-Schutz AC and Teixeira KN interpreted the data, performed the critical analysis of the results, corrected the manuscript and coordinated the study; All authors approved the final version of the manuscript.
Institutional review board statement: The Institutional Review Board declares knowledge about the study.
Institutional animal care and use committee statement: The Institutional Animal Care and Use Committee declares knowledge and approval about the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that all data are public and can be shared upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kádima Nayara Teixeira, PhD, Professor, Campus Toledo, Universidade Federal do Paraná, Max Planck 3796, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Received: November 19, 2022
Peer-review started: November 19, 2022
First decision: February 1, 2023
Revised: March 12, 2023
Accepted: April 10, 2023
Article in press: April 10, 2023
Published online: May 7, 2023
Processing time: 168 Days and 9.5 Hours
Core Tip

Core Tip: Keto-alcoholic extracts derived from the leaves and bark of Lafoensia pacari (L. pacari) demonstrate significant analgesic/antinociceptive activity in a murine acetic acid-induced pain model of colitis. These results can likely be extrapolated to humans, as the identities and structures of mouse and human cyclooxygenase-2 (COX-2) are similar. Furthermore, mouse and human COX-2 interacted in a similar fashion with L. pacari extract flavonoids when tested in silico. Extracts from both the leaves and bark of L. pacari were found to improve inflammation and pain symptoms in mice with acetic acid-induced acute colitis.