Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2023; 29(16): 2469-2478
Published online Apr 28, 2023. doi: 10.3748/wjg.v29.i16.2469
Older adults with acute severe ulcerative colitis have similar steroid non-response and colectomy rates as younger adults
Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Laura Willmann, Hadi Moattar, Maneesha Bhullar, Naveed Ishaq, Alexander Dorrington, Dheeraj Shukla, Carolyn McIvor, John Edwards, Waled Mohsen
Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Laura Willmann, Hadi Moattar, Maneesha Bhullar, Naveed Ishaq, Alexander Dorrington, Dheeraj Shukla, John Edwards, Waled Mohsen, Department of Digestive Diseases, Gold Coast University Hospital, Gold Coast 4215, Queensland, Australia
Carolyn McIvor, Department of Gastroenterology, Logan Hospital, Logan 4131, Queensland, Australia
Author contributions: Subhaharan D, Ramaswamy PK and Mohsen W designed the study and performed data analysis; Subhaharan D, Ramaswamy PK, Willmann L, Moattar H, Bhullar M, Ishaq N, Dorrington A, Shukla D, McIvor C, Edwards J, and Mohsen W performed literature review and manuscript writing; and all authors have read and approve the final manuscript.
Institutional review board statement: The study was approved by the Gold Coast Health Service Human Research Ethics Committee (Ref: LNR/2020/QGC/67173).
Informed consent statement: Due to the retrospective design of the study, the requirement for informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deloshaan Subhaharan, MD, Doctor, Department of Digestive Diseases, Gold Coast University Hospital, 1 Hospital Boulevard, Southport, Gold Coast 4215, Queensland, Australia. deloshaan.subhaharan@health.qld.gov.au
Received: November 15, 2022
Peer-review started: November 15, 2022
First decision: February 2, 2023
Revised: February 11, 2023
Accepted: March 24, 2023
Article in press: March 24, 2023
Published online: April 28, 2023
Core Tip

Core Tip: This is a retrospective study to assess the outcomes of older adults (≥ 60 years of age) hospitalised with acute severe ulcerative colitis (ASUC) as per Truelove and Witts’ criteria. We identified 45 episodes of ASUC in older adults and compared outcomes with 181 episodes of ASUC in patients < 60 years of age. Older adults with ASUC have similar steroid non-response rate, response to medical rescue therapy and colectomy rates up to 12 mo from index admission, when compared to patients less than 60 years of age.