Review
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World J Gastroenterol. Apr 28, 2023; 29(16): 2433-2451
Published online Apr 28, 2023. doi: 10.3748/wjg.v29.i16.2433
Ferroptosis regulates key signaling pathways in gastrointestinal tumors: Underlying mechanisms and therapeutic strategies
Ravichandiran Rabitha, Sethuraman Shivani, Yahya Showket, Ganapasam Sudhandiran
Ravichandiran Rabitha, Sethuraman Shivani, Yahya Showket, Ganapasam Sudhandiran, Department of Biochemistry, University of Madras, Cell Biology Research Laboratory, Chennai 600 025, Tamil Nadu, India
Author contributions: Rabitha R and Shivani S collected the data and equally wrote the paper; Showket Y and Sudhandiran G in part wrote and revised the manuscript and analyzed the data; Shivani S, Showket Y, and Sudhandiran G created the figures.
Conflict-of-interest statement: All authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ganapasam Sudhandiran, MPhil, PhD, Full Professor, Department of Biochemistry, University of Madras, Cell Biology Research Laboratory, Gandhi Mandapam Road, Chennai 600 025, Tamil Nadu, India. sudhandiran@unom.ac.in
Received: December 11, 2022
Peer-review started: December 11, 2022
First decision: January 11, 2023
Revised: January 26, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: April 28, 2023
Processing time: 134 Days and 1.9 Hours
Core Tip

Core Tip: Gastrointestinal tumors contribute to the majority of cancer-related deaths. Ferroptosis is a novel form of non-apoptotic cell death that plays a vital role in reducing the invasiveness and metastasis of gastrointestinal tumors. Herein, we discussed the regulatory mechanisms involved in ferroptosis through the hallmark pathways of glutathione peroxidase 4, iron metabolism, lipid peroxidation, and redox signaling that provide a novel therapeutic approach for gastrointestinal cancers.