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World J Gastroenterol. Apr 28, 2023; 29(16): 2380-2396
Published online Apr 28, 2023. doi: 10.3748/wjg.v29.i16.2380
Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
Lie Zheng, Sheng-Lei Duan
Lie Zheng, Sheng-Lei Duan, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an 730000, Shaanxi Province, China
Author contributions: Zheng L contributed to the conception and design of the study and performed to the writing of the manuscript; Zheng L and Duan SL contributed to literature search, drafting of the manuscript, and providing approval of the final version to be published.
Supported by Shaanxi Province Natural Science Basic Research Program-General Project, No: 2019JM-580; Project of Shaanxi Administration of Traditional Chinese Medicine, No. 2019-ZZ-JC010; Key R&D Projects in Shaanxi Province, No. 2021SF-314.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lie Zheng, MD, Researcher, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 4 Xihuamen Street, Lianhu District, Xi’an 730000, Shaanxi Province, China. liezhenglie@163.com
Received: September 18, 2022
Peer-review started: September 18, 2022
First decision: November 26, 2022
Revised: January 26, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: April 28, 2023
Processing time: 218 Days and 11.1 Hours
Core Tip

Core Tip: Intestinal mucosal injury is an important pathological change in ulcerative colitis (UC), and Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-positive intestinal stem cells play an important role in the repair of intestinal mucosal injury. Through in-depth study of multiple signals, LGR5-positive intestine stem cell transplantation therapy may become an important means to treat UC.