Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2023; 29(15): 2241-2260
Published online Apr 21, 2023. doi: 10.3748/wjg.v29.i15.2241
Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer
Akash Bararia, Prosenjeet Chakraborty, Paromita Roy, Bitan Kumar Chattopadhay, Amlan Das, Aniruddha Chatterjee, Nilabja Sikdar
Akash Bararia, Nilabja Sikdar, Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, India
Prosenjeet Chakraborty, Department of Molecular Biosciences, SVYASA School of Yoga and Naturopathy, Bangalore 560105, India
Paromita Roy, Department of Pathology, Tata Medical Center, Kolkata 700160, India
Bitan Kumar Chattopadhay, Department of General Surgery, IPGMER & SSKM Hospital, Kolkata 700020, India
Amlan Das, Department of Biochemistry, Royal Global University, Assam 781035, India
Aniruddha Chatterjee, Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9061, New Zealand
Aniruddha Chatterjee, School of Health Sciences and Technology, University of Petroleum and Energy Studies, Dehradun 248007, India
Author contributions: Bararia A and Chakraborty P wrote the first draft of the paper and constructed the flow chart and tables; Chatterjee A, Roy P, Chattopadhay B K, Das A and Sikdar N provided valuable input, suggestions, comments and guidance while writing the review manuscript and contributed to proofreading and editing; Sikdar N constructed, wrote, conceptualized, and edited the review manuscript.
Supported by the Department of Biotechnology, Government of India Grant Sanction, Ramalingaswami Re-entry Fellowship, No. RLS/BT/Re-entry/05/2012.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nilabja Sikdar, PhD, Research Scientist, Doctor, Human Genetics Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata 700108, India. snilabja@isical.ac.in
Received: November 28, 2022
Peer-review started: November 28, 2022
First decision: January 11, 2023
Revised: February 2, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 21, 2023
Processing time: 136 Days and 23.7 Hours
Core Tip

Core Tip: Considering the limited commercial availability of cell free nucleic acids and secreted proteome-based non-invasive biomarkers it is crucial to summarize them for the proper diagnosis of pancreatic cancer and distinguish it from other benign pancreatic diseases. We also highlighted the clinical use of these non-invasive biomarkers in diagnostics. This review will successfully guide readers to address the current issues and aid in the cutting-edge development of biomarkers with higher sensitivity and specificity.