Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis
Cai-Song Chen, Research Center for High Altitude Medicine of Qinghai University, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Yao-Gang Zhang, Hai-Jiu Wang, Qinghai Province Research Key Laboratory for Echinococcosis, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Hai-Ning Fan, Department of Hepatobiliary and Pancreatic Surgery, Qinghai Province Research Key Laboratory for Echinococcosis, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Author contributions: Chen CS and Fan HN conceived and designed the experiments; Chen CS, Zhang YG, and Wang HJ collected the samples; Chen CS and Zhang YG performed the experiments and data analyses; Chen CS wrote the first draft of the manuscript; Zhang YG and Fan HN provided comments for the revisions; all authors read and approved the final manuscript.
Supported by the National Major Research and Development Project of “Precision Medicine Research”, No. 2017YFC0909900; Qinghai Province Science and Technology Department Programme, No. 2019-SF-131; and the Qinghai Province Health and Family Planning Commission Programme, No. 2016-wjzd-04.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Affiliated Hospital of Qinghai University (approval No. P-SL-2019054).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee of the Affiliated Hospital of Qinghai University (approval No. 2019-SF-131).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Hai-Ning Fan, MD, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, Qinghai Province Research Key Laboratory for Echinococcosis, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. fanhaining6@yeah.net
Received: December 17, 2022
Peer-review started: December 17, 2022
First decision: January 22, 2023
Revised: February 1, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 14, 2023
