Zou YG, Wang H, Li WW, Dai DL. Challenges in pediatric inherited/metabolic liver disease: Focus on the disease spectrum, diagnosis and management of relatively common disorders. World J Gastroenterol 2023; 29(14): 2114-2126 [PMID: 37122598 DOI: 10.3748/wjg.v29.i14.2114]
Corresponding Author of This Article
Dong-Ling Dai, DPhil, MD, PhD, Chief Doctor, Professor, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases and Endoscopy Center, Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen 518026, Guangdong Province, China. daidong3529@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 14, 2023; 29(14): 2114-2126 Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2114
Challenges in pediatric inherited/metabolic liver disease: Focus on the disease spectrum, diagnosis and management of relatively common disorders
Yi-Gui Zou, Huan Wang, Wen-Wen Li, Dong-Ling Dai
Yi-Gui Zou, Huan Wang, Wen-Wen Li, Dong-Ling Dai, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases and Endoscopy Center, Shenzhen Children's Hospital, Shenzhen 518026, Guangdong Province, China
Author contributions: Zou YG, Wang H and Li WW drafted the manuscript; Dai DL critically edited, revised and finalized the manuscript; Zou YG, Wang H and Li WW contributed equally to this manuscript; all of the authors approved the submission of this manuscript.
Supported bythe Shenzhen Science and Technology Innovation Program, No. JCYJ20220818102801004 (to Dai DL).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Ling Dai, DPhil, MD, PhD, Chief Doctor, Professor, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases and Endoscopy Center, Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen 518026, Guangdong Province, China. daidong3529@sina.com
Received: December 23, 2022 Peer-review started: December 23, 2022 First decision: January 3, 2023 Revised: January 9, 2023 Accepted: March 21, 2023 Article in press: March 21, 2023 Published online: April 14, 2023 Processing time: 111 Days and 2.1 Hours
Core Tip
Core Tip: The spectrum of diseases causing pediatric liver dysfunction has been changing, and an increasing number of inherited/metabolic disorders have been increasingly recognized as major contributors to liver disease in children. Etiological diagnosis remains challenging due to the frequent absence of symptoms or nonspecific signs and limited diagnostic approaches, especially liver biopsy, which is not easily accepted by pediatric patients. Consequently, the treatment of pediatric inherited/ metabolic liver disease is challenging. In this manuscript, we review here the challenges in pediatric inherited/metabolic liver disease, including epidemiological changes in the disease spectrum and challenges in etiological diagnosis and treatment.
