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World J Gastroenterol. Apr 7, 2023; 29(13): 1982-1993
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1982
Research progress on the mitochondrial mechanism of age-related non-alcoholic fatty liver
Dan Wang, Duo-Chun Ji, Chun-Yan Yu, Dan-Ni Wu, Ling Qi
Dan Wang, Duo-Chun Ji, Chun-Yan Yu, Dan-Ni Wu, College of Basic Medicine, Beihua University, Jilin 132013, Jilin Province, China
Ling Qi, Central Laboratory, Qingyuan People's Hospital, Qingyuan 511518, Guangdong Province, China
Author contributions: All authors performed the literature review and wrote the manuscript; Ji DC and Wu DN drew and modified the illustrations; Yu CY, Wang D and Qi L critically reviewed and revised the manuscript.
Supported by Jilin Provincial Department of Science and Technology, No. YDZJ202101ZYTS090.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling Qi, PhD, Professor, Central Laboratory, Qingyuan People's Hospital, Area B24, Yinquan Road, Qingyuan 511518, Guangdong Province, China. qiling1718@gzhmu.edu.cn
Received: January 9, 2023
Peer-review started: January 9, 2023
First decision: February 7, 2023
Revised: February 20, 2023
Accepted: March 9, 2023
Article in press: March 9, 2023
Published online: April 7, 2023
Processing time: 87 Days and 17 Hours
Core Tip

Core Tip: The elderly are prone to a series of pathological damages such as liver fibrosis due to the decline of liver regeneration ability and immune response dysfunction. In addition, liver metabolism imbalance and mitochondrial dysregulation play a key role in the development of non-alcoholic fatty liver disease (NAFLD). And a treatment strategy for NAFLD was proposed in terms of abnormal lipid metabolism, mitophagy, and anti-oxidation, which provided new ideas for the development of innovative drugs for the prevention and treatment of NAFLD.