Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2023; 29(13): 1969-1981
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1969
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1969
Liver transplantation in the management of cholangiocarcinoma: Evolution and contemporary advances
Aditya Borakati, Farid Froghi, Department of HPB and Liver Transplantation Surgery, Royal Free Hospital NHS Foundation Trust, London NW3 2QG, United Kingdom
Ricky H Bhogal, Vasileios K Mavroeidis, Department of Academic Surgery, The Royal Marsden NHS Foundation Trust, London SW3 6JJ, United Kingdom
Author contributions: Mavroeidis VK conceptualised and designed the study; Borakati A and Mavroeidis VK did the literature search; Borakati A and Froghi F did the analysis, interpretation of data and drafted the original manuscript; Bhogal RH and Mavroeidis VK supervised and made critical revisions; All authors prepared the final draft and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vasileios K Mavroeidis, MD, MSc, FRCS, FACS, FICS, MFSTEd, Surgeon, Department of Academic Surgery, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, United Kingdom. vasileios.mavroeidis@nhs.net
Received: December 6, 2022
Peer-review started: December 6, 2022
First decision: February 1, 2023
Revised: February 10, 2023
Accepted: March 21, 2023
Article in press: March 21, 2023
Published online: April 7, 2023
Peer-review started: December 6, 2022
First decision: February 1, 2023
Revised: February 10, 2023
Accepted: March 21, 2023
Article in press: March 21, 2023
Published online: April 7, 2023
Core Tip
Core Tip: Cholangiocarcinoma (CCA) is an aggressive malignancy with poor prognosis. Radical surgical resection with clear margins may offer a chance of cure but is frequently not possible due to locally advanced disease. In the last two decades, within specific criteria, a protocolised combination of neoadjuvant chemoradiation and orthotopic liver transplantation (LT) has produced excellent results in patients with perihilar CCA, while favourable results have been shown with LT in early intrahepatic CCA in recent years. We review the history and contemporary advances of LT in CCA and discuss future perspectives.