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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2023; 29(13): 1911-1941
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.1911
Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer
Sheng-Nan Ren, Zhan-Yi Zhang, Rui-Jie Guo, Da-Ren Wang, Fang-Fang Chen, Xue-Bo Chen, Xue-Dong Fang
Sheng-Nan Ren, Fang-Fang Chen, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Zhan-Yi Zhang, Rui-Jie Guo, Da-Ren Wang, Bethune Third Clinical Medical College, Jilin University, Changchun 130021, Jilin Province, China
Xue-Bo Chen, Xue-Dong Fang, Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Author contributions: Ren SN and Zhang ZY reviewed the literature and wrote the paper; Zhang ZY designed and draw the figures; Guo RJ, Wang DR, and Chen FF performed the collected data; Fang XD and Chen XB initiated the idea and revised the manuscript; all authors have read and approved the final manuscript.
Supported by the Natural Science Foundation of Jilin Province, No. 20210101433JC.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Bo Chen, MD, Doctor, Professor, Department of Gastrointestinal, Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin Province, China. chenxb@jlu.edu.cn
Received: September 25, 2022
Peer-review started: September 25, 2022
First decision: January 3, 2023
Revised: February 2, 2023
Accepted: March 21, 2023
Article in press: March 21, 2023
Published online: April 7, 2023
Processing time: 194 Days and 2.2 Hours
Core Tip

Core Tip: Mechanisms of Colorectal cancer (CRC) cell resistance can be attributed to tumoral and environmental factors, the former of which includes gene expression alteration, signaling pathway activation, metabolic rewiring, and the later refers to complicated adaptions regarding cancer associated fibroblast, immune cells, hypoxic conditions. Taking efforts to conquer therapeutic resistance is imperative to improve CRC patients` survival. Nanotechnology possesses distinct advantages to increase specificity of treatment and realize codelivery of multiple drugs, which facilitates to restore sensitivity to antitumor therapy, and modulate suppressive tumor microenvironment to stimulatory environment.