Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2023; 29(11): 1651-1668
Published online Mar 21, 2023. doi: 10.3748/wjg.v29.i11.1651
Microbiome-liver crosstalk: A multihit therapeutic target for liver disease
Jorum Kirundi, Sheida Moghadamrad, Camilla Urbaniak
Jorum Kirundi, Department of Biomedical Research, University of Bern, Bern 3014, Switzerland
Sheida Moghadamrad, Department of Gastroenterology/Hepatology, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona and Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano 6900, Switzerland
Camilla Urbaniak, ZIN Technologies, Middleburg Heights, OH 44130, United States
Author contributions: Kirundi J conceived, wrote, and edited the manuscript; Moghadamrad S made the figure and edited the manuscript; Urbaniak C conceived and edited the manuscript. All authors contributed equally in the responses to the reviewers. All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Camilla Urbaniak, PhD, Research Scientist, ZIN Technologies, Middleburg Heights, OH 44130, United States.
Received: September 21, 2022
Peer-review started: September 21, 2022
First decision: November 5, 2022
Revised: January 5, 2023
Accepted: March 7, 2023
Article in press: March 7, 2023
Published online: March 21, 2023
Core Tip

Core Tip: The influence of the gut microbiome on various body systems has important implications for health and disease, such as liver disease. While the exact mechanisms of how the microbiome contributes to liver disease are unknown, there is strong evidence that the translocation of various metabolites across the mucosal barrier plays a strong role, which is precipitated by dysbiotic gut microbiota. Considering the importance of the microbiome in liver disease, powerful therapeutic options that can manipulate the gut microbiome are being explored. These approaches could have the potential for effective treatments for various stages of liver disease. This review will explore how the mechanisms of colonization resistance influence the liver in health and disease and finally examine potential therapeutic targets in the gut-liver axis.