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World J Gastroenterol. Mar 7, 2022; 28(9): 897-908
Published online Mar 7, 2022. doi: 10.3748/wjg.v28.i9.897
Dualistic role of platelets in living donor liver transplantation: Are they harmful?
Chen Liang, Kazuhiro Takahashi, Kinji Furuya, Nobuhiro Ohkohchi, Tatsuya Oda
Chen Liang, Kazuhiro Takahashi, Kinji Furuya, Nobuhiro Ohkohchi, Tatsuya Oda, Gastrointestinal and Hepatobiliary-Pancreatic Surgery, University of Tsukuba, Tsukuba 3058575, Ibaraki, Japan
Author contributions: Liang C, Takahashi K, Furuya K, Ohkohchi N, and Oda T contributed equally to this work; Liang C and Takahashi K wrote the paper; all authors provided final approval of the version that was submitted.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kazuhiro Takahashi, MD, PhD, Assistant Professor, Surgeon, Gastrointestinal and Hepatobiliary-Pancreatic Surgery, University of Tsukuba, Tennodai 1-1-1, Tsukuba 3058575, Ibaraki, Japan. kazu1123@md.tsukuba.ac.jp
Received: May 19, 2021
Peer-review started: May 19, 2021
First decision: June 24, 2021
Revised: July 4, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: March 7, 2022
Core Tip

Core Tip: Perioperative thrombocytopenia is considered to be associated with poor graft regeneration and postoperative morbidity in the short and long term after living donor liver transplantation (LDLT). This review presented recent evidence for the role of platelets in LDLT based on clinical and basic studies. Platelets have both beneficial and detrimental effects on liver grafts, with a generally positive role in liver regeneration and a potentially negative role in ischemia/reperfusion injury. As increasing perioperative platelet counts are suggested to improve graft regeneration and survival, “platelet therapy” may provide prophylactic or therapeutic strategies to enhance the beneficial effects of LDLT.