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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2022; 28(8): 811-824
Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.811
Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.811
Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum
Qiao-Li Jiang, You Lu, Meng-Jie Zhang, Zhen-Yu Cui, Zhong-Mei Pei, Wen-Hua Li, Ying-Ying Lu, Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China
Lun-Gen Lu, Ying-Ying Lu, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
Jing-Jing Wang, Shanghai Key Laboratory of Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
Author contributions: Jiang QL and Lu Y equally contributed on this manuscript, designed and conceived the experiments; Lu Y and Li WH collected patient samples and data; Jiang QL, Zhang MJ, Cui ZY and Pei ZM performed the 16S rRNA sequencing data analysis; Jiang QL and Lu YY acquired and analyzed data, wrote the manuscript; Lu YY and Wang JJ provided guidance for sample processing methodology; Lu LG reviewed the manuscript; all authors approved the final version of the article.
Supported by the Science and Technology Project of Jiading Hospital , Shanghai General Hospital, No. 202134A and No. 202125A.
Institutional review board statement: The study was reviewed and approved by the Reseach Ethics Boards of the Shanghai General Hospital (2021KY085).
Informed consent statement: The written informed consent was obtained from all the patients before sample collection.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Ying Lu, PhD, Associate Chief Physician, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Songjiang Road, Shanghai 201620, China. le_voyageur@qq.com
Received: October 1, 2021
Peer-review started: October 1, 2021
First decision: November 7, 2021
Revised: November 19, 2021
Accepted: January 14, 2022
Article in press: January 14, 2022
Published online: February 28, 2022
Processing time: 146 Days and 9.1 Hours
Peer-review started: October 1, 2021
First decision: November 7, 2021
Revised: November 19, 2021
Accepted: January 14, 2022
Article in press: January 14, 2022
Published online: February 28, 2022
Processing time: 146 Days and 9.1 Hours
Core Tip
Core Tip: Nodular lymphoid hyperplasia (NLH) in the small intestine is a rare benign lesion characterized by multiple small nodules on the surface of the intestine. To explore the correlation between the intestinal flora and terminal ileal NLH, we performed bacterial 16S rRNA gene sequencing of mucosal samples from patients with terminal ileal NLH. Our results reveal that specific microflora may act on the mucosa of the small intestine and cause terminal ileal NLH. Therefore, maintaining the balance of intestinal flora and supplementing targeted protective bacteria may improve terminal ileal NLH symptoms and potentially reduce the risk of lymphoma transformation.