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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2022; 28(7): 745-754
Published online Feb 21, 2022. doi: 10.3748/wjg.v28.i7.745
Published online Feb 21, 2022. doi: 10.3748/wjg.v28.i7.745
Stereotactic radiotherapy and the potential role of magnetic resonance-guided adaptive techniques for pancreatic cancer
Tai Ermongkonchai, Richard Khor, Sweet Ping Ng, Department of Radiation Oncology, Olivia Newton-John Cancer Centre at Austin Health, Heidelberg 3084, Victoria, Australia
Vijayaragavan Muralidharan, Department of Surgery, Austin Health, Heidelberg 3084, Victoria, Australia
Niall Tebbutt, Department of Medical Oncology, Olivia Newton-John Cancer Centre at Austin Health, Heidelberg 3084, Victoria, Australia
Kelvin Lim, Numan Kutaiba, Department of Diagnostic Radiology, Austin Health, Heidelberg 3084, Victoria, Australia
Author contributions: Ermongkonchai T performed the literature search and wrote the manuscript; Khor R, Muralidharan V, Tebbutt N, Lim K, Kutaiba N and Ng SP performed editing and contributed to the quality of the manuscript.
Conflict-of-interest statement: No conflict-of-interest to be declared by authors of this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sweet Ping Ng, MBBS, PhD, Associate Professor, Department of Radiation Oncology, Olivia Newton-John Cancer Centre at Austin Health, 145 Studley Road, Heidelberg 3084, Victoria, Australia. sweetping.ng@austin.org.au
Received: September 13, 2021
Peer-review started: September 13, 2021
First decision: October 16, 2021
Revised: November 11, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: February 21, 2022
Processing time: 157 Days and 1.1 Hours
Peer-review started: September 13, 2021
First decision: October 16, 2021
Revised: November 11, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: February 21, 2022
Processing time: 157 Days and 1.1 Hours
Core Tip
Core Tip: Locally advanced pancreatic cancer has very poor outcomes. These cases are treated with chemoradiotherapy regimens, but conventional radiotherapy techniques often yield minimal survival benefit while accruing significant toxicities. Stereotactic body radiotherapy (SBRT) is an advanced technique that is associated with improved survival outcomes and reduced toxicities compared to its predecessors. The addition of Magnetic resonance-guided techniques to SBRT provides excellent imaging that enables intra-treatment plan adaptations. This provides the possibility of dose escalation, which may be the key to achieving surgical resectability and thus potentially increasing the chances of cure.