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World J Gastroenterol. Feb 14, 2022; 28(6): 624-634
Published online Feb 14, 2022. doi: 10.3748/wjg.v28.i6.624
Recent advances in the diagnostic evaluation of pancreatic cystic lesions
Devarshi R Ardeshna, Troy Cao, Brandon Rodgers, Chidiebere Onongaya, Dan Jones, Wei Chen, Eugene J Koay, Somashekar G Krishna
Devarshi R Ardeshna, Chidiebere Onongaya, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Troy Cao, Brandon Rodgers, College of Medicine, Ohio State University, Columbus, OH 43210, United States
Dan Jones, James Molecular Laboratory, Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Wei Chen, Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Eugene J Koay, Department of GI Radiation Oncology, The University of Texas MD Anderson, Houston, TX77030, United States
Somashekar G Krishna, Division of Gastroenterology, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Author contributions: Ardeshna DR, Cao T, Rodgers B, Onongaya C, Krishna SG performed the majority of the literature search, writing, and preparation of tables/figures; Jones D, Chen W, Koay EJ and Krishna SG provided input in the writing process and review of the final manuscript.
Conflict-of-interest statement: Krishna SG is the principal investigator of an investigator-initiated study. The study in part is funded by a grant to The Ohio State University Wexner Medical Center from Mauna Kea Technologies, Paris, France.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Somashekar G Krishna, AGAF, FACG, FASGE, MD, Professor, Division of Gastroenterology, Department of Internal Medicine, Ohio State University Wexner Medical Center, 395 W. 12th Avenue, Suite 262, Columbus, OH 43210, United States. somashekar.krishna@osumc.edu
Received: May 29, 2021
Peer-review started: May 29, 2021
First decision: June 22, 2021
Revised: July 30, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 14, 2022
Processing time: 256 Days and 6.6 Hours
Core Tip

Core Tip: Pancreatic cystic lesions (PCLs) are highly prevalent. It is critical to accurately diagnose PCLs and risk stratify them to guide management. Current diagnostic techniques are suboptimal; hence, recent investigations have focused on developing, refining, and validating novel technologies for accurately diagnosing specific cyst type and ascertaining high-risk lesions for malignancy. Radiomics, cyst-fluid biomarkers, confocal laser endomicroscopy and microforceps biopsy hold the promise of accurately diagnosing PCLs and improving their management.