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World J Gastroenterol. Dec 21, 2022; 28(47): 6702-6715
Published online Dec 21, 2022. doi: 10.3748/wjg.v28.i47.6702
Microbiota in the stomach and application of probiotics to gastroduodenal diseases
Yasuhiro Koga
Yasuhiro Koga, Japanese Society for Probiotic Science, Isehara 259-1143, Japan
Author contributions: Koga Y alone designed and wrote the manuscript.
Conflict-of-interest statement: No conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yasuhiro Koga, MD, PhD, Professor, Japanese Society for Probiotic Science, Isehara 259-1143, Japan.
Received: August 17, 2022
Peer-review started: August 17, 2022
First decision: October 20, 2022
Revised: October 28, 2022
Accepted: November 25, 2022
Article in press: November 25, 2022
Published online: December 21, 2022
Core Tip

Core Tip: Gastric microbiota and application of probiotics to the gastroduodenal diseases have so far been unfamiliar because the mass of live microbes is so small in the stomach with high acidity. However, in the subject whose stomach is low acidity due to atrophic gastritis or proton pump inhibitor long-use, the number of live bacteria increases so much in the stomach thus they can significantly influence the pathophysiology of gastroduodenal diseases.