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World J Gastroenterol. Dec 7, 2022; 28(45): 6345-6355
Published online Dec 7, 2022. doi: 10.3748/wjg.v28.i45.6345
The mononuclear phagocyte system in hepatocellular carcinoma
Duan-Rui Qiao, Guan-Yue Shan, Shuai Wang, Jun-Ya Cheng, Wei-Qun Yan, Hai-Jun Li
Duan-Rui Qiao, Jun-Ya Cheng, Wei-Qun Yan, Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130021, Jilin Province, China
Duan-Rui Qiao, Guan-Yue Shan, Shuai Wang, Jun-Ya Cheng, Hai-Jun Li, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Shuai Wang, Department of Students Affairs, China-Japan Union Hospital of Jilin University, Changchun 130031, Jilin Province, China
Hai-Jun Li, Institute of Liver Diseases, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Author contributions: Shan GY and Wang S collected the information; Cheng JY drew and modified the illustrations; Qiao DR wrote the paper; Li HJ and Yan WQ revised the paper.
Supported by National Natural Science Foundation of China, No 81970529; and The Natural Science Foundation of Jilin Province, No. 20200201387JC.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No.71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn
Received: July 15, 2022
Peer-review started: July 15, 2022
First decision: September 1, 2022
Revised: October 10, 2022
Accepted: November 16, 2022
Article in press: November 16, 2022
Published online: December 7, 2022
Core Tip

Core Tip: The hepatocellular carcinoma (HCC) is a complex disease affected or initiated by many factors, including chronic hepatitis B virus infection, hepatitis C virus infection, metabolic disorders or alcohol consumption. Innate immune system can shape the acquired immune response, which can surveillance HCC directly. As the main component of innate immunity, the mononuclear phagocyte system (MPS) plays a vital role in HCC. In this review, we outline the impact of HCC on MPS. We illustrate how HCC reshapes MPS cell phenotype remodeling and producing the associated cytokines, and characterize the function and impairment of MPS in HCC.