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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2022; 28(42): 6068-6077
Published online Nov 14, 2022. doi: 10.3748/wjg.v28.i42.6068
Published online Nov 14, 2022. doi: 10.3748/wjg.v28.i42.6068
Computed tomography perfusion in liver and spleen for hepatitis B virus-related portal hypertension: A correlation study with hepatic venous pressure gradient
Lei Wang, Department of Intervention Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Yu Zhang, Yi-Fan Wu, Zhen-Dong Yue, Zhen-Hua Fan, Fu-Quan Liu, Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Chun-Yan Zhang, Jian Dong, Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: Dong J, Liu FQ, and Wang L designed the report; Zhang Y, Wu YF, Yue ZD, Fan ZH, and Zhang CY collected the clinical data; Wang L and Zhang Y analyzed and wrote the paper; Dong J and Liu FQ performed quality control; Liu FQ contributed to administrative and financial support; all authors have read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China General Program , No. 81871461 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Beijing Shijitan Hospital, Capital Medical University (Approval No. 201801).
Clinical trial registration statement: This study is registered at ClinicalTrials.gov: http://www.chictr.org.cn/edit.aspx?pid=26048&htm=4. The registration identification number is ChiCTR1800015268.
Informed consent statement: Written informed consent was obtained from each patient.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Dong, MD, Doctor, Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Street, Haidian District, Beijing 100038, China. dongjianradiology@163.com
Received: August 7, 2022
Peer-review started: August 7, 2022
First decision: August 31, 2022
Revised: October 14, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 14, 2022
Peer-review started: August 7, 2022
First decision: August 31, 2022
Revised: October 14, 2022
Accepted: October 31, 2022
Article in press: October 31, 2022
Published online: November 14, 2022
Core Tip
Core Tip: Hepatic venous pressure gradient (HVPG) is the gold standard for the diagnosis of portal hypertension (PH), but its use is limited because it is an invasive procedure. Non-invasive assessment of HVPG requires further research. Computed tomography perfusion of the liver may be a useful tool for the evaluation of HVPG. Our results showed that a cutoff of 17.85 mL/min/100 g for liver blood volume yielded an 80% sensitivity and 89% specificity for severe PH. Therefore, computed tomography perfusion of the liver has the potential as a non-invasive quantitative predictor for PH in hepatitis B virus-related liver cirrhosis.