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World J Gastroenterol. Oct 21, 2022; 28(39): 5691-5706
Published online Oct 21, 2022. doi: 10.3748/wjg.v28.i39.5691
Interplay between metabolic dysfunction-associated fatty liver disease and chronic kidney disease: Epidemiology, pathophysiologic mechanisms, and treatment considerations
Panagiotis Theofilis, Aikaterini Vordoni, Rigas G Kalaitzidis
Panagiotis Theofilis, Aikaterini Vordoni, Rigas G Kalaitzidis, Center for Nephrology “G. Papadakis,” General Hospital of Nikaia-Piraeus “Agios Panteleimon,” Nikaia 18454, Greece
Author contributions: Theofilis P contributed to conceiving the study; Theofilis P and Vordoni A contributed to the investigation; Theofilis P contributed to the visualization; Kalaitzidis RG contributed to the supervision; Theofilis P and Vordoni A wrote the original draft; Kalaitzidis RG edited the original draft; All authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Panagiotis Theofilis, MD, Doctor, Researcher, Center for Nephrology “G. Papadakis,” General Hospital of Nikaia-Piraeus “Agios Panteleimon,” Piraeus, Nikaia 18454, Greece.
Received: August 12, 2022
Peer-review started: August 12, 2022
First decision: August 29, 2022
Revised: September 6, 2022
Accepted: September 19, 2022
Article in press: September 19, 2022
Published online: October 21, 2022
Core Tip

Core Tip: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a recently defined pathological state aiming to identify individuals at increased risk of adverse prognosis. Numerous epidemiological studies propose that chronic kidney disease may be among its complications. Their shared risk factors, molecular mechanisms, and genetic predisposition represent the basis for this relationship. Accordingly, treatment approaches with combined efficacy in MAFLD and chronic renal impairment are expected to positively impact the natural history of this deleterious interaction, which remains to be confirmed in future studies.