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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2022; 28(35): 5111-5128
Published online Sep 21, 2022. doi: 10.3748/wjg.v28.i35.5111
Published online Sep 21, 2022. doi: 10.3748/wjg.v28.i35.5111
Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease
Mohamed Zaiou, Institut Jean Lamour, UMR CNRS 7198, CNRS, University of Lorraine, Nancy 54011, France
Author contributions: Zaiou M conducted the literature review and wrote the manuscript.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed Zaiou, PhD, Professor, Institut Jean Lamour, UMR CNRS 7198, CNRS, University of Lorraine, 2 allée André Guinier, BP 50840, Nancy 54011, France. mohamed.zaiou@univ-lorraine.fr
Received: July 15, 2022
Peer-review started: July 15, 2022
First decision: July 25, 2022
Revised: July 28, 2022
Accepted: August 25, 2022
Article in press: August 25, 2022
Published online: September 21, 2022
Peer-review started: July 15, 2022
First decision: July 25, 2022
Revised: July 28, 2022
Accepted: August 25, 2022
Article in press: August 25, 2022
Published online: September 21, 2022
Core Tip
Core Tip: Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of hepatic pathologies, ranging from simple steatosis to nonalcoholic steatohepatitis, all of which can evolve to cirrhosis and in some cases to hepatocellular carcinoma. There are now indications that noncoding RNAs (ncRNAs), a component of epigenetic mechanisms, contribute to the pathogenesis of NAFLD and may serve as potential prognostic and diagnostic biomarkers. However, little is known about the role of these RNA species in NAFLD and its progressive forms. This paper discusses the current state of research on the role of most clinically relevant ncRNAs in the pathogenesis of NAFLD.