Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2022; 28(32): 4635-4648
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4635
The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway
Jun-Jian Liu, Yan Xu, Shuai Chen, Cheng-Fei Hao, Jing Liang, Zhong-Lian Li
Jun-Jian Liu, Cheng-Fei Hao, Zhong-Lian Li, The Second Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University NanKai Hospital, Tianjin 300102, China
Yan Xu, Graduate School, Tianjin Medical University, Tianjin 3000070, China
Shuai Chen, Department of Thoracic Surgery, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221000, Jiangsu Province, China
Jing Liang, School of Foreign Languages, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, Sichuan Province, China
Author contributions: Liu JJ, Xu Y, and Li ZL designed and coordinated the study; Liu JJ, Xu Y, and Chen S performed the experiments and acquired the data; Xu Y, Chen S, and Hao CF analyzed the data; Liu JJ, and Xu Y wrote the manuscript; Liang J proofread the manuscript; and All authors approved the final version of the article.
Supported by the Scientific and Technological Project in Key Areas of Traditional Chinese Medicine of Tianjin Municipal Health and Health Committee, China, No. 2019003; and the Integrated Traditional Chinese and Western Medicine Project of Tianjin Municipal Health and Health Committee, China, No. 2021042.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Tianjin Medical University Nankai Hospital.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (license No. SCXK Jin 2020-0008). The experimental protocol was approved by the Animal Research Committee of Tianjin Medical University Nankai Hospital (approval No. NKYY-DWLL-2021-102).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, The Second Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University NanKai Hospital, No. 6 Changjiang Street, Nankai District, Tianjin 300102, China. nkyylzl@163.com
Received: March 24, 2022
Peer-review started: March 24, 2022
First decision: May 30, 2022
Revised: June 8, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: August 28, 2022
Core Tip

Core tip: Obstructive Jaundice (OJ) may cause liver injury through various mechanisms. Traditional Chinese medicine has lots of advantages in treating OJ. The mechanism of Yinchenhao decoction (YCHD) for treating OJ-induced liver injury has made significant progress in recent years, but it is still unclear. We used the network pharmacology approach to predict the active components and putative targets of YCHD. We created the OJ rat models and through randomized controlled trials, concluded that YCHD could alleviate liver injury and oxidative damage, thereby promoting the translocation of NF-E2 related factor 2 (Nrf2) to the nucleus, and upregulating the Nrf2 signaling pathway.