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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2022; 28(32): 4557-4573
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4557
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4557
Liver regeneration as treatment target for severe alcoholic hepatitis
Lucija Virovic-Jukic, Sanja Stojsavljevic-Shapeski, Neven Ljubičić, Department of Gastroenterology and Hepatology, Sisters of Charity University Hospital Center, Zagreb 10000, Croatia
Lucija Virovic-Jukic, Dominik Ljubas, Neven Ljubičić, Tajana Filipec Kanizaj, Ivica Grgurevic, Department of Internal Medicine, University of Zagreb School of Medicine, Zagreb 10000, Croatia
Neven Ljubičić, Department of Internal Medicine, University of Zagreb School of Dental Medicine, Zagreb 10000, Croatia
Tajana Filipec Kanizaj, Department of Gastroenterology, Merkur University Hospital, Zagreb 10000, Croatia
Ivana Mikolasevic, Department of Gastroenterology, Rijeka University Hospital Center, Rijeka 51000, Croatia
Ivana Mikolasevic, Department of Internal Medicine, University of Rijeka School of Medicine, Rijeka 10000, Croatia
Ivica Grgurevic, Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb 10000, Croatia
Author contributions: Virovic-Jukic L designed the study, performed literature search, outlined the manuscript and revised it; Ljubas D performed literature search and writing; Stojsavljevic-Shapeski S designed the study and outlined the manuscript; Ljubičić N, Filipec Kanizaj T, Mikolasevic I and Grgurevic I revised the manuscript for important intellectual content.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lucija Virovic-Jukic, Doctor, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Sisters of Charity University Hospital Center, Vinogradska cesta 29, Zagreb 10000, Croatia. lucija.virovic.jukic@kbcsm.hr
Received: February 26, 2022
Peer-review started: February 26, 2022
First decision: May 9, 2022
Revised: May 30, 2022
Accepted: June 16, 2022
Article in press: June 16, 2022
Published online: August 28, 2022
Peer-review started: February 26, 2022
First decision: May 9, 2022
Revised: May 30, 2022
Accepted: June 16, 2022
Article in press: June 16, 2022
Published online: August 28, 2022
Core Tip
Core Tip: Current treatment options for patients with severe alcoholic hepatitis (AH) are unsatisfactory, resulting in high mortality rates. Liver regeneration is impaired in patients with severe AH and represents an appealing therapeutic target. Granulocyte-colony stimulating factor, alone or in combination with stem cell therapy represents a promising therapeutic option for severe AH. Contrary to animal and several small human studies, evidence from recent studies failed to show benefit of these liver regeneration therapies in patients with advanced alcohol related liver disease.