Minireviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2022; 28(32): 4527-4539
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4527
Impact of microbiota-immunity axis in pancreatic cancer management
Ilenia Bartolini, Giulia Nannini, Matteo Risaliti, Francesco Matarazzo, Luca Moraldi, Maria Novella Ringressi, Antonio Taddei, Amedeo Amedei
Ilenia Bartolini, Matteo Risaliti, Francesco Matarazzo, Maria Novella Ringressi, Antonio Taddei, Department of Experimental and Clinical Medicine, HPB Surgery Unit, Azienda Ospedaliero-Universitaria Careggi, Florence 50134, Italy
Giulia Nannini, Amedeo Amedei, Department of Experimental and Clinical Medicine, SOD of Interdisciplinary Internal Medicine, Azienda Ospedaliera-Universitaria Careggi, Florence 50134, Italy
Luca Moraldi, Division of Oncologic Surgery, Department of Oncology, Careggi University Hospital, Firenze 50134, Italy
Author contributions: Bartolini I, Nannini G, and Risaliti M contributed to writing—original draft preparation; all the authors contributed to conceptualization and design of the study, critical revision of the article, and final approval of the version of the paper; Taddei A and Amedei A supervised this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amedeo Amedei, PhD, Professor, Department of Experimental and Clinical Medicine, SOD of Interdisciplinary Internal Medicine, Azienda Ospedaliera-Universitaria Careggi, Largo Brambilla 3, Florence 50134, Italy. amedeo.amedei@unifi.it
Received: January 19, 2022
Peer-review started: January 19, 2022
First decision: May 29, 2022
Revised: June 28, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 28, 2022
Processing time: 218 Days and 11 Hours
Core Tip

Core Tip: Despite improvements in traditional patient treatment, pancreatic cancer remains a tumor with an increasing incidence and a poor prognosis, often diagnosed in late stages. The oral, gut, biliary, and intrapancreatic microbiota might contribute to pancreatic cancer through different pathways including a complex interplay with the immune system. Comprehending these complicated relationships could help researchers better understand the pathogenesis of pancreatic cancer, thus providing new promising options for early diagnosis, therapeutic targets, and risk stratification hoping that could translate into better and longer patient survival.